PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF BERBERIS INTEGERRIMA BUNGE. ROOT ON CARBON TETRACHLORIDE-INDUCED TESTICULAR INJURY IN WISTAR RATS

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RAFIEE FERESHTEH; NEJATI VAHID; HEIDARI REZA; ASHRAF HOSSEIN

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Journal: International Journal of Reproductive BioMedicine Year:2016 | Volume:14 | Issue:2 Page(s): 133-140

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Title

PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF BERBERIS INTEGERRIMA BUNGE. ROOT ON CARBON TETRACHLORIDE-INDUCED TESTICULAR INJURY IN WISTAR RATS

Author(s)

RAFIEE FERESHTEH | NEJATI VAHID | HEIDARI REZA | ASHRAF HOSSEIN | Issue Writer Certificate

Keywords

BERBERIS

ANTIOXIDANT

CARBON TETRACHLORIDE

TESTIS

RATS

Abstract

Background: Tissue protective effect of compounds with ANTIOXIDANT properties has been demonstrated. The alkaloids found in barberry root are considered as ANTIOXIDANTs.Objective: According to barberry protective effects in different tissues, in this study, the protective effect of BERBERIS integerrima Bge. root (MEBIR) was evaluated against CCl4-induced testicular damages in Wistar RATS.Materials and Methods: 40 mature male RATS were randomly divided into 5 groups: 1: Normal control, 2: Sham: received CCl4 diluted in olive oil (50% v/v; 1ml/kg bw), intraperitoneally, twice a week for 4 weeks, 3 and 4: Sham RATS treated with MEBIR (250 and 500 mg/kg bw) for 28 days, 5: Sham RATS treated with silymarin (50 mg/kg bw) for 28 days. After 28 days, serum testosterone level, absolute TESTIS weight, catalase activity, malondialdehyde level, and histological parameters were investigated.Results: In the treated RATS with MEBIR (250 and 500 mg/kg bw) or silymarin (50 mg/kg bw), there was a significant increase in the absolute TESTIS weight, testosterone level, seminiferous tubules diameter (p<0.001), thickness of the epithelium, tubule differentiation index (p<0.001), spermiogenesis index (p<0.001), the activity of catalase, and a significant decrease in interstitial tissue thickness (p<0.001) and malondialdehyde level in comparison with CCl4-treated group. The effect of the MEBIR at dose of 500 mg/kg bw is more than that of the standard drug, silymarin (50 mg/kg bw).Conclusion: From the results, it is suggested that the protective effects of MEBIR is possibly due to ANTIOXIDANT effects of its bioactive compounds.

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APA: Copy

RAFIEE, FERESHTEH, NEJATI, VAHID, HEIDARI, REZA, & ASHRAF, HOSSEIN. (2016). PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF BERBERIS INTEGERRIMA BUNGE. ROOT ON CARBON TETRACHLORIDE-INDUCED TESTICULAR INJURY IN WISTAR RATS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 14(2), 133-140. SID. https://sid.ir/paper/296255/en

Vancouver: Copy

RAFIEE FERESHTEH, NEJATI VAHID, HEIDARI REZA, ASHRAF HOSSEIN. PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF BERBERIS INTEGERRIMA BUNGE. ROOT ON CARBON TETRACHLORIDE-INDUCED TESTICULAR INJURY IN WISTAR RATS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2016;14(2):133-140. Available from: https://sid.ir/paper/296255/en

IEEE: Copy

FERESHTEH RAFIEE, VAHID NEJATI, REZA HEIDARI, and HOSSEIN ASHRAF, “PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF BERBERIS INTEGERRIMA BUNGE. ROOT ON CARBON TETRACHLORIDE-INDUCED TESTICULAR INJURY IN WISTAR RATS,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 14, no. 2, pp. 133–140, 2016, [Online]. Available: https://sid.ir/paper/296255/en

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