Intra uterine extra-amniotic versus vaginal misoprostol for termination of second trimester miscarriage: A randomized controlled trial

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Abbas Mitwaly Abo Bakr; Abbas Ahmed Mohamed; Sayed Abdellah Mohamed

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Journal: International Journal of Reproductive BioMedicine Year:2016 | Volume:14 | Issue:10 Page(s): 643-648

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Title

Intra uterine extra-amniotic versus vaginal misoprostol for termination of second trimester miscarriage: A randomized controlled trial

Author(s)

Abbas Mitwaly Abo Bakr | Abbas Ahmed Mohamed | Sayed Abdellah Mohamed | Issue Writer Certificate

Keywords

Misoprostol

Missed miscarriage

Termination of pregnancy

Prostaglandins

Abstract

Background: Termination of pregnancy in the second trimester using Prostaglandins has been shown to be safe and effective. Misoprostol has multiple routes of administration; oral, vaginal, buccal, rectal and sublingual. Objective: The study aims to compare the efficacy and safety of intrauterine extra-amniotic and vaginal Misoprostol in a dose of 200 microgram every 4 hours for the Termination of pregnancy in cases of second trimester miscarriage. Materials and Methods: A prospective randomized open labeled clinical trial included 180 women with Missed miscarriage in gestational age between 13 and 24 wks. Patients were randomized to receive subsequent doses of 200 μ g Misoprostol every 4 hrs either intra uterine extra-amniotic by Foley catheter or vaginally administered. Randomization was completed using a computer-generated random table. The primary outcome of this study was the mean duration from the initial Misoprostol dose until complete fetal expulsion (induction-expulsion interval). Results: The mean gestational age was 17. 74 wks. The mean time to complete miscarriage in the intra uterine extra-amniotic group was 5. 27 hrs, which was significantly lower than the vaginal group (9. 92 hrs, p=0. 001). Side effects were more common in vaginal group. Conclusion: Intra uterine extra-amniotic Misoprostol with a dose of 200 μ g every 4 hrs appears to be more effective and safer than vaginal Misoprostol in induction of second trimester miscarriage.

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APA: Copy

Abbas Mitwaly, Abo Bakr, Abbas, Ahmed Mohamed, & Sayed Abdellah, Mohamed. (2016). Intra uterine extra-amniotic versus vaginal misoprostol for termination of second trimester miscarriage: A randomized controlled trial. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 14(10), 643-648. SID. https://sid.ir/paper/296308/en

Vancouver: Copy

Abbas Mitwaly Abo Bakr, Abbas Ahmed Mohamed, Sayed Abdellah Mohamed. Intra uterine extra-amniotic versus vaginal misoprostol for termination of second trimester miscarriage: A randomized controlled trial. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2016;14(10):643-648. Available from: https://sid.ir/paper/296308/en

IEEE: Copy

Abo Bakr Abbas Mitwaly, Ahmed Mohamed Abbas, and Mohamed Sayed Abdellah, “Intra uterine extra-amniotic versus vaginal misoprostol for termination of second trimester miscarriage: A randomized controlled trial,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 14, no. 10, pp. 643–648, 2016, [Online]. Available: https://sid.ir/paper/296308/en

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