THE EFFECT OF RESVERATROL ON OXIDATIVE STRESS IN THE LIVER AND SERUM OF A RAT MODEL OF POLYCYSTIC OVARY SYNDROME: AN EXPERIMENTAL STUDY

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GHOWSI MAHNAZ; KHAZALI HOMAYOUN; SISAKHTNEZHAD SAJJAD

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:2018 | Volume:16 | Issue:3 Page(s): 149-158

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Title

THE EFFECT OF RESVERATROL ON OXIDATIVE STRESS IN THE LIVER AND SERUM OF A RAT MODEL OF POLYCYSTIC OVARY SYNDROME: AN EXPERIMENTAL STUDY

Author(s)

GHOWSI MAHNAZ | KHAZALI HOMAYOUN | SISAKHTNEZHAD SAJJAD | Issue Writer Certificate

Keywords

OXIDATIVE STRESS

POLYCYSTIC OVARY SYNDROME

RESVERATROL

LIVER

Abstract

Background: Studies of oxidative status in polycystic ovarian syndrome (PCOS) patients are limited with inconsistent results. The effects of RESVERATROL as a natural antioxidant on oxidative status in PCOS aren’t clear.Objective: This study evaluated effects of RESVERATROL on OXIDATIVE STRESS in the LIVER and serum of the PCOS rats.Materials and Methods: Fifteen female Wistar rats (3 wk old) were divided into 3 groups (n=5/each e): Control group, PCO-Control group, and PCO-Resveratrol group. For induction of polycystic ovary phenotype, testosterone enanthate 10 mg/kg was injected for 35 days subcutaneously. Then, RESVERATROL 10 mg/kg was injected intraperitoneally for 28 days to rats of the PCO-Resveratrol group. Ovarian sections were stained with hematoxylin/eosin. The serum glucose and insulin and the levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) in serum and LIVER were measured.Results: Control animals showed normal ovarian morphology and PCO-Control animals exhibited cystic follicles. There were no significant differences in LIVER TAC between groups. The serum MDA (p=0.034), and homeostatic model assessment insulin resistance (HOMA-IR) (p=0.014) levels in PCO-Control rats were higher than the controls. The LIVER MDA in PCO-Control rats was more than that of controls (p=0.001). The HOMA-IR (p=0.008) and serum MDA (p=0.006) levels in PCO-Control rats were more than those of PCO-Resveratrol rats (p=0.008). In PCOResveratrol group, serum TAC was higher than that of PCO-Control group (p=0.022) and LIVER MDA was more than controls (p=0.01).Conclusion: Results indicated that the induction of PCOS in rats increased lipid peroxidation and insulin resistance and RESVERATROL improved these complications.

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Evaluation of Antioxidant Capacity and Cotinine Levels of Saliva in Male Smokers and Non-smokers

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APA: Copy

GHOWSI, MAHNAZ, KHAZALI, HOMAYOUN, & SISAKHTNEZHAD, SAJJAD. (2018). THE EFFECT OF RESVERATROL ON OXIDATIVE STRESS IN THE LIVER AND SERUM OF A RAT MODEL OF POLYCYSTIC OVARY SYNDROME: AN EXPERIMENTAL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(3), 149-158. SID. https://sid.ir/paper/296343/en

Vancouver: Copy

GHOWSI MAHNAZ, KHAZALI HOMAYOUN, SISAKHTNEZHAD SAJJAD. THE EFFECT OF RESVERATROL ON OXIDATIVE STRESS IN THE LIVER AND SERUM OF A RAT MODEL OF POLYCYSTIC OVARY SYNDROME: AN EXPERIMENTAL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(3):149-158. Available from: https://sid.ir/paper/296343/en

IEEE: Copy

MAHNAZ GHOWSI, HOMAYOUN KHAZALI, and SAJJAD SISAKHTNEZHAD, “THE EFFECT OF RESVERATROL ON OXIDATIVE STRESS IN THE LIVER AND SERUM OF A RAT MODEL OF POLYCYSTIC OVARY SYNDROME: AN EXPERIMENTAL STUDY,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 3, pp. 149–158, 2018, [Online]. Available: https://sid.ir/paper/296343/en

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