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Information Journal Paper

Title

Heavy metals, biomarkers of oxidative stress and changes in sperm function: A case-control study

Pages

  163-174

Abstract

 Background: Heavy metal-induced Oxidative stress has been implicated in abnormal Sperm functions and male infertility. Objective: Serum and seminal levels of Heavy metals and biomarkers of Oxidative stress were compared in fertile and infertile men. Materials and Methods: A total of 130 men aged 20– 60 yr comprising 30 azoospermic, 50 oligozoospermic, and 50 normozoospermic men were studied. Semen analysis was done by world health organization guidelines, biomarkers of Oxidative stress (total antioxidant capacity (TAC), total plasma peroxidase (TPP), Oxidative stress index (OSI), vitamin C (vit C) and nitric oxide (NO)) and fructose by colorimetry and serum and seminal Heavy metals (zinc (Zn), selenium (Se), cadmium (Cd) and lead (Pb)) by atomic absorption spectrophotometry. Results: Azoospermic and oligozoospermic men had higher serum and seminal peroxides (TPP, p = 0. 00), higher serum Heavy metals (Zn, Se, Pb, and Cd (p = 0. 01)) and lower sperm concentration, %motility, serum and seminal Antioxidants (vit C, TAC, NO, GSH (p = 0. 01)) compared to normozoospermic men. Higher seminal peroxides (TPP, p = 0. 001), Heavy metals (Pb and Cd (p = 0. 03)) and lower sperm concentration, %motility, and seminal Antioxidants (TAC and NO (p = 0. 00)) were also observed in azoospermic men compared to oligozoospermic men. Negative correlations were observed between seminal fructose and seminal vit C (r =-0. 535, p = 0. 015), GSH (r =-0. 734, p = 0. 000), NO (r =-0. 714, p = 0. 000), Zn (r =-0. 774, p = 0. 000) and Se (r =-0. 719, p = 0. 000) only in azoospermic men. Conclusion: Elevated heavy metal levels, increased Lipid peroxidation and antioxidant depletion is associated with abnormal Sperm functions in men studied.

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    APA: Copy

    NSONWU ANYANWU, AUGUSTA CHINYERE, Ekong, Eworo Raymond, Offor, Sunday Jeremiah, Awusha, Ogar Francis, Orji, Oliver Chukwuma, Umoh, Ediang Idiongo, Owhorji, Jennifer Aleruchim, Emetonjor, Faith Rowland, & Opara Usoro, Chinyere Adanna. (2019). Heavy metals, biomarkers of oxidative stress and changes in sperm function: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(3), 163-174. SID. https://sid.ir/paper/296357/en

    Vancouver: Copy

    NSONWU ANYANWU AUGUSTA CHINYERE, Ekong Eworo Raymond, Offor Sunday Jeremiah, Awusha Ogar Francis, Orji Oliver Chukwuma, Umoh Ediang Idiongo, Owhorji Jennifer Aleruchim, Emetonjor Faith Rowland, Opara Usoro Chinyere Adanna. Heavy metals, biomarkers of oxidative stress and changes in sperm function: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(3):163-174. Available from: https://sid.ir/paper/296357/en

    IEEE: Copy

    AUGUSTA CHINYERE NSONWU ANYANWU, Eworo Raymond Ekong, Sunday Jeremiah Offor, Ogar Francis Awusha, Oliver Chukwuma Orji, Ediang Idiongo Umoh, Jennifer Aleruchim Owhorji, Faith Rowland Emetonjor, and Chinyere Adanna Opara Usoro, “Heavy metals, biomarkers of oxidative stress and changes in sperm function: A case-control study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 3, pp. 163–174, 2019, [Online]. Available: https://sid.ir/paper/296357/en

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