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Cites:

Information Journal Paper

Title

Effects of different doses of tamoxifen on the sperm parameters and chromatin quality in mice: An experimental model

Pages

  279-286

Keywords

Abstract

 Background: Tamoxifen (TX) is widely used for the treatment of male factor and idiopathic infertility. It has been shown that TX induces Sperm production and so improves male fertility. Objective: This study evaluated the effects of different doses of TX on the Sperm parameters and Chromatin quality in Mice. Materials and Methods: In this research, 24 male NMRI Mice were divided into three groups including group A: control animal receiving vehicle; group B: the group receiving basal diet and TX 0. 4 mg/kg/day; and group C: the group receiving basal diet and TX 0. 6 mg/kg/day for 35 days. Thereafter, epididymal Spermatozoa were analyzed for standard parameters and nuclear Chromatin quality using Aniline Blue (AB) and Toluidine Blue (TB) staining. Results: The results indicated that although the TX did not affect the Sperm count, motility, and viability parameters, it could elevate the percentage of Sperm cells with abnormal morphology and abnormal Chromatin at both doses. In addition, in comparison with the control Mice, a significant elevation was observed in Spermatozoa with residual histones (assessed by AB staining) at high doses of TX. Conclusion: Our experimental data in Mice suggested that the use of TX for treating male infertility might increase the rates of Spermatozoa with abnormal Chromatin in a dose-dependent manner.

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    APA: Copy

    SADEGHI, SEPIDEH, TALEBI, ALI REZA, SHAHEDI, ABBAS, MOEIN, MOHAMMAD REZA, & ABBASI SARCHESHMEH, ABOLGHASEM. (2019). Effects of different doses of tamoxifen on the sperm parameters and chromatin quality in mice: An experimental model. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(4), 279-286. SID. https://sid.ir/paper/296367/en

    Vancouver: Copy

    SADEGHI SEPIDEH, TALEBI ALI REZA, SHAHEDI ABBAS, MOEIN MOHAMMAD REZA, ABBASI SARCHESHMEH ABOLGHASEM. Effects of different doses of tamoxifen on the sperm parameters and chromatin quality in mice: An experimental model. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(4):279-286. Available from: https://sid.ir/paper/296367/en

    IEEE: Copy

    SEPIDEH SADEGHI, ALI REZA TALEBI, ABBAS SHAHEDI, MOHAMMAD REZA MOEIN, and ABOLGHASEM ABBASI SARCHESHMEH, “Effects of different doses of tamoxifen on the sperm parameters and chromatin quality in mice: An experimental model,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 4, pp. 279–286, 2019, [Online]. Available: https://sid.ir/paper/296367/en

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