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Information Journal Paper

Title

Granulocyte colony-stimulating factor gene rs1042658 variant and susceptibility to idiopathic recurrent pregnancy loss: A case-control study

Pages

  35-40

Abstract

 Background: Granulocyte colony-in stimulating factor (G-CSF) gene can be a potential candidate gene implicated Recurrent pregnancy loss (RPL), a common complication of pregnancy with the prevalence of 1-5% among women of reproductive age. Objective: To investigate the association between rs1042658 Polymorphism in the 3' untranslated region (3'UTR) of G-CSF gene and the risk of unexplained RPL among Iranian women. Materials and Methods: In total, 122 women with unexplained RPL and 140 healthy postmenopausal women as a control group were enrolled in this case-control study. Tetra-primer amplification refractory mutation system-polymerase chain reaction was performed to determine the rs1042658 genotypes in all subjects. Results: Statistically significant differences were detected between the distribution frequencies of both heterozygote CT, and carriage of T allele (TT+CT) genotypes of the rs1042658 between case and control groups. Allelic association was not observed with RPL. Conclusion: Regarding the results of the present study, G-CSF rs1042658 gene Polymorphism could be considered as a probable risk factor for unexplained RPL among Iranian women.

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    APA: Copy

    NASIRI, MAHBOOBEH, & Jahangirizadeh, Kobra. (2018). Granulocyte colony-stimulating factor gene rs1042658 variant and susceptibility to idiopathic recurrent pregnancy loss: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(1), 35-40. SID. https://sid.ir/paper/296418/en

    Vancouver: Copy

    NASIRI MAHBOOBEH, Jahangirizadeh Kobra. Granulocyte colony-stimulating factor gene rs1042658 variant and susceptibility to idiopathic recurrent pregnancy loss: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(1):35-40. Available from: https://sid.ir/paper/296418/en

    IEEE: Copy

    MAHBOOBEH NASIRI, and Kobra Jahangirizadeh, “Granulocyte colony-stimulating factor gene rs1042658 variant and susceptibility to idiopathic recurrent pregnancy loss: A case-control study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 1, pp. 35–40, 2018, [Online]. Available: https://sid.ir/paper/296418/en

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