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Information Journal Paper

Title

N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT

Pages

  203-208

Abstract

 Background: N-acetyl cysteine (NAC) was proposed as an adjuvant to clomiphene citratefor Ovulation induction in patients with Polycystic ovary syndrome (PCOS) without clomiphene citrate resistance. Objective: To evaluate the effect of NAC on pregnancy rate in PCOS patients who were candidates for Intrauterine insemination. Materials and Methods: In this randomized clinical trial 97 PCOS women aged 18-38 years were enrolled in two groups, randomly. For the case group (n=49), NAC (1. 2 gr)+ clomiphene citrate (100 mg) + letrozole (5mg) were prescribed Daily from the third day of menstruation cycle for five days. The control group (n=48) had the same drug regimen without NAC. In order to follicular development, GONALF was injected on days of 7-11 menstrual cycles in all participants. When the follicle size was 18mm or more, HCG (10000 IU) was injected intramuscular and the Intrauterine insemination was performed after 34-36 hr. Results: There were not significant differences between study groups regarding mean endometrial thickness (p=0. 14), mean number of mature follicles (p=0. 20) and the pregnancy rate (p=0. 09). Conclusion: NAC is ineffective in inducing or augmenting ovulation in PCOS patients who were candidates for Intrauterine insemination and cannot be recommended as an adjuvant to CC in such patients.

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    APA: Copy

    BEHROUZI LAK, TAHEREH, HAJSHAFIHA, MASOMEH, NANBAKHSH, FARIBA, & OSHNOUEI, SIMA. (2017). N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 15(4), 203-208. SID. https://sid.ir/paper/296428/en

    Vancouver: Copy

    BEHROUZI LAK TAHEREH, HAJSHAFIHA MASOMEH, NANBAKHSH FARIBA, OSHNOUEI SIMA. N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2017;15(4):203-208. Available from: https://sid.ir/paper/296428/en

    IEEE: Copy

    TAHEREH BEHROUZI LAK, MASOMEH HAJSHAFIHA, FARIBA NANBAKHSH, and SIMA OSHNOUEI, “N-acetyl cysteine in ovulation induction of PCOS women underwent intrauterine insemination: An RCT,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 15, no. 4, pp. 203–208, 2017, [Online]. Available: https://sid.ir/paper/296428/en

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