مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Imatinib alters cell viability but not growth factors levels in TM4 Sertoli cells

Pages

  577-582

Abstract

 Background: The anticancer agent imatinib (IM) is a small molecular analog of ATP that inhibits tyrosine kinase activity of Platelet derived growth factors (PDGFs) and Stem cell factor (SCF) receptor in cancer cells. However these factors have a key role in regulating growth and development of normal Sertoli, Leydig and germ cells. Objective: The aim of this study was to determine Cell viability, PDGF and SCF levels in mouse normal Sertoli cells exposed to IM. Materials and Methods: In this experimental study, the mouse TM4 Sertoli cells were treated with 0, 2. 5, 5, 10 and 20 μ M IM for 2, 4 or 6 days. The Cell viability and growth factors levels were assessed by MTT and ELISA methods, respectively. For statistical analysis, One-Way ANOVA was performed. Results: IM showed significant decrease in Sertoli Cell viability compared to control group (p=0. 001). However, IM increased PDGF and SCF level insignificantly (p>0. 05). Conclusion: Results suggested that IM treatment induced a dose dependent reduction of Cell viability in Sertoli cells. It seems that treatment with this anticancer drug is involved in the fertility process. Further studies are needed to evaluate the role of PDGF and SCF in this cell. Key

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    APA: Copy

    HASHEMNIA, SEYYED MOHAMMAD REZA, ATARI HAJIPIRLOO, SOMAYEH, ROSHAN MILANI, SHIVA, VALIZADEH, NASIM, Mahabadi, sonya, & KHERADMAND, FATEMEH. (2016). Imatinib alters cell viability but not growth factors levels in TM4 Sertoli cells. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 14(9), 577-582. SID. https://sid.ir/paper/296437/en

    Vancouver: Copy

    HASHEMNIA SEYYED MOHAMMAD REZA, ATARI HAJIPIRLOO SOMAYEH, ROSHAN MILANI SHIVA, VALIZADEH NASIM, Mahabadi sonya, KHERADMAND FATEMEH. Imatinib alters cell viability but not growth factors levels in TM4 Sertoli cells. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2016;14(9):577-582. Available from: https://sid.ir/paper/296437/en

    IEEE: Copy

    SEYYED MOHAMMAD REZA HASHEMNIA, SOMAYEH ATARI HAJIPIRLOO, SHIVA ROSHAN MILANI, NASIM VALIZADEH, sonya Mahabadi, and FATEMEH KHERADMAND, “Imatinib alters cell viability but not growth factors levels in TM4 Sertoli cells,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 14, no. 9, pp. 577–582, 2016, [Online]. Available: https://sid.ir/paper/296437/en

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