Prothrombin gene mutations do not cause recurrent pregnancy loss in the Indian population (Letter to Editor)

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Reddy Ravindranath; Mutreja Deepti; Mukhopadhyay Indrani; Moorchung Nikhil

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Journal: International Journal of Reproductive BioMedicine Year:2019 | Volume:17 | Issue:5 Page(s): 375-376

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Title

Prothrombin gene mutations do not cause recurrent pregnancy loss in the Indian population (Letter to Editor)

Author(s)

Reddy Ravindranath | Mutreja Deepti | Mukhopadhyay Indrani | Moorchung Nikhil | Issue Writer Certificate

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Abstract

Dear Editor, As defined by the American Society of Reproductive Medicine, recurrent miscarriage or recurrent pregnancy loss is defined as two or more failed pregnancies. (1). There are various causes for RPL and yet, in about 40% of cases, no cause can be identified after extensive investigation. It is believed that inherited and acquired thrombophilia like Protein C/S deficiency and genetic mutations in the Factor V and the Prothrombin gene maybe a cause of RPL (2). There is a significant association between the Prothrombin G2021M mutation (PTG) with RPL which has been shown by numerous other studies (3). The data with respect to PTG G20210A mutations and its association with RPL is scant in Indian population. In this study, we evaluated a total of 56 women in this point prevalence cross-sectional study. The sample size was determined on the basis of the number of women attending the antenatal OPD (n-10000), the RPL prevalence in the general population (1%), and the Confidence Interval (5%). The sample size was calculated by the EPI Info software. The sample size was calculated as 38.

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APA: Copy

Reddy, Ravindranath, Mutreja, Deepti, Mukhopadhyay, Indrani, & Moorchung, Nikhil. (2019). Prothrombin gene mutations do not cause recurrent pregnancy loss in the Indian population (Letter to Editor). INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(5), 375-376. SID. https://sid.ir/paper/296444/en

Vancouver: Copy

Reddy Ravindranath, Mutreja Deepti, Mukhopadhyay Indrani, Moorchung Nikhil. Prothrombin gene mutations do not cause recurrent pregnancy loss in the Indian population (Letter to Editor). INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(5):375-376. Available from: https://sid.ir/paper/296444/en

IEEE: Copy

Ravindranath Reddy, Deepti Mutreja, Indrani Mukhopadhyay, and Nikhil Moorchung, “Prothrombin gene mutations do not cause recurrent pregnancy loss in the Indian population (Letter to Editor),” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 5, pp. 375–376, 2019, [Online]. Available: https://sid.ir/paper/296444/en

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