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Information Journal Paper

Title

Effects of pentoxifylline on the histological and ultrastructural features of vitrified mouse ovarian tissue: An experimental study

Pages

  387-396

Abstract

 Background: Vitrification is a process that can be used to preserve gonads in the healthy and natural status. Oxidative stress is one of the disadvantages of Vitrification. Pentoxifylline (PTX) is an antioxidant that can reduce reactive oxidative stress effects. Objective: We aimed to investigate the effects of PTX on histological and ultrastructural features of vitrified and non-vitrified Mouse ovarian tissue. Materials and Methods: Twenty-five adult female Balb-C mice were randomly and equally divided into control group: the ovaries did not receive any treatment; experimental 1 and 2: the vitrified ovaries were incubated in phosphate buffer solution and bovine serum albumin without and with PTX, respectively, for 30 min; sham 1 and 2: the non-vitrified ovaries were incubated in phosphate buffer solution and bovine serum albumin and were incubated without and with PTX, respectively for 30 min. The right and left ovaries in all of the groups were evaluated using light and transmission electron microscopy, respectively. Results: The histological and ultra-structural features of vitrified ovaries were seriously damaged. There was non-uniformed germinal epithelium and tunica albuginea, degenerated granulosa cells and stromal cells, puffy basement membrane and irregular thickness of zona pellucida, as well as a pyknotic nucleus and bubbly and segmented ooplasmic in the follicles. Also, ovarian tissues were damaged by the PTX in the non-vitrified ovaries. Conclusion: Vitrification can damage the histological and ultra-structural features of the Ovary in Mouse models. PTX as an antioxidant, with concentration of 1. 8 mM could not prevent and restore these damages and had no adequate effects on the vitrified ovarian tissues.

Cites

References

Cite

APA: Copy

ALIABADI, ELHAM, MESBAH, FAKHRODDIN, Kargar Abarghouei, Elias, ZAHIRI, SHAHLA, & ABDI, SHABNAM. (2018). Effects of pentoxifylline on the histological and ultrastructural features of vitrified mouse ovarian tissue: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(6), 387-396. SID. https://sid.ir/paper/296452/en

Vancouver: Copy

ALIABADI ELHAM, MESBAH FAKHRODDIN, Kargar Abarghouei Elias, ZAHIRI SHAHLA, ABDI SHABNAM. Effects of pentoxifylline on the histological and ultrastructural features of vitrified mouse ovarian tissue: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(6):387-396. Available from: https://sid.ir/paper/296452/en

IEEE: Copy

ELHAM ALIABADI, FAKHRODDIN MESBAH, Elias Kargar Abarghouei, SHAHLA ZAHIRI, and SHABNAM ABDI, “Effects of pentoxifylline on the histological and ultrastructural features of vitrified mouse ovarian tissue: An experimental study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 6, pp. 387–396, 2018, [Online]. Available: https://sid.ir/paper/296452/en

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