EFFECT OF PENTOXIFYLLINE AND VITAMIN E ON OVARIAN FOLLICLES IN RATS

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KHORAMI S.; FARROKHI F.; TUKMECHI A.; NOOROZI R.

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Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2013 | Volume:15 | Issue:3 Page(s): 64-73

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Information Journal Paper

Title

EFFECT OF PENTOXIFYLLINE AND VITAMIN E ON OVARIAN FOLLICLES IN RATS

Author(s)

KHORAMI S. | FARROKHI F. | TUKMECHI A. | NOOROZI R. | Issue Writer Certificate

Keywords

OVARIAN FOLLICLESQ2

PENTOXIFYLLINEQ2

RATQ2

VITAMIN EQ2

Abstract

Background and aims: Injection of agents that scavenge oxidative radicals into the ovarian bursa of mouse could reduce ovulation RATe. VITAMIN E as a powerful antioxidant inhibits reactive oxygen species, and on the other hand, PENTOXIFYLLINE improves capillary blood stream and tissue oxygenation. The aim of this study was to evaluate the effects of these compounds on the growth of OVARIAN FOLLICLES in RAT.Methods: In this laboratory experimental study, 32 female RATs were divided into four groups: control (injected with physiology serum), VITAMIN E (intramuscular injection of 100 mg/kg once a day), PENTOXIFYLLINE (50 mg /kg, given orally once a day), and combination of PENTOXIFYLLINE and VITAMIN E (with the same concentration). After a 28-day treatment, RATs were anesthetized, ovaries were removed from each RAT separately, and tissue section stained with Hematoxylin- Eosin and Sudan Black for light microscopic examination.Results: A significant decrease in corpus luteum, primary follicles, and graph follicles number was observed in the experimental groups compared to the control (P<0.05). In addition, the number of atretic follicles in the experimental groups was higher than the control (P<0.05).Conclusion: VITAMIN E and PENTOXIFYLLINE have antioxidant property that negatively affect on the maturation of OVARIAN FOLLICLES.

Cites

Effects of pentoxifylline on the histological and ultrastructural features of vitrified mouse ovarian tissue: An experimental study

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APA: Copy

KHORAMI, S., FARROKHI, F., TUKMECHI, A., & NOOROZI, R.. (2013). EFFECT OF PENTOXIFYLLINE AND VITAMIN E ON OVARIAN FOLLICLES IN RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 15(3), 64-73. SID. https://sid.ir/paper/58398/en

Vancouver: Copy

KHORAMI S., FARROKHI F., TUKMECHI A., NOOROZI R.. EFFECT OF PENTOXIFYLLINE AND VITAMIN E ON OVARIAN FOLLICLES IN RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;15(3):64-73. Available from: https://sid.ir/paper/58398/en

IEEE: Copy

S. KHORAMI, F. FARROKHI, A. TUKMECHI, and R. NOOROZI, “EFFECT OF PENTOXIFYLLINE AND VITAMIN E ON OVARIAN FOLLICLES IN RATS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 3, pp. 64–73, 2013, [Online]. Available: https://sid.ir/paper/58398/en

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