مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Triage by cervical length sonographic measurements for targeted therapy in threatened preterm labor: A double blind randomized clinical trial

Pages

  697-702

Abstract

 Background: Preterm labor and birth are associated with several neonatal complications including respiratory distress syndrome and intraventricular hemorrhage. Differentiating true and false labor pain is a dilemma to obstetricians. Objective: To elucidate the role of Cervical length measurement in prediction of birth in pregnant women with threatened Preterm labor. Materials and Methods: In this double blind randomized clinical trial, 120 women with gestational age <34 wk who presented painful uterine contractions randomly assigned to undergo measurement of Cervical length. Patients were registered in the hospital and a unit number was given. Based on the unit numbers, patients were randomly assigned to two groups using a computerized random digit generator. All participants were managed accordingly (n=65) or to receive Tocolysis as planned (n=55). Tocolysis was prescribed when Cervical length was <15 mm while those with Cervical length ≥ 15 mm were managed expectantly. Delivery within 7 days of the presentation was the primary outcome. Results: This RCT showed in case group, 78. 9% of patient with Cervical length <15 mm were delivered within 7 days and only 21. 1% of them maintained their pregnancy. Of those with Cervical length ≥ 15 mm, only 15. 2% were delivered within the study period and the rest (84. 8%) maintained their pregnancy (p<0. 001). Conclusion: “ Our results indicate that in women who presented Preterm labor symptoms, Cervical length measurement will result in decreased unnecessary tocolytic treatment. Women with Cervical length ≥ 15mm should not receive Tocolysis, however, withholding corticosteroid therapy in these patients needs further evidence.

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