The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance

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Firmansyah Arini; Chalid Maisuri Tadjuddin; Farid Retno Budiati; Abdullah Nusratuddin

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:2018 | Volume:16 | Issue:11 Page(s): 679-682

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Title

The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance

Author(s)

Firmansyah Arini | Chalid Maisuri Tadjuddin | Farid Retno Budiati | Abdullah Nusratuddin | Issue Writer Certificate

Keywords

Insulin-like growth factor binding protein 1

Insulin resistance

Polycystic ovarian syndrome

Abstract

Background: The underlying etiology of Polycystic ovarian syndrome (PCOS) is unknown and assumed to have a strong correlation with Insulin resistance. Homeostasis Model Assessment of Insulin resistance (HOMA-IR) is a good tool to assess Insulin resistance. Low levels of serum Insulin-like Growth Factor-Binding Protein-1 (IGFBP-1) in PCOS women led to the hypothesis that hyperinsulinemia in PCOS inhibits the production of IGFBP-1, which in turn stimulates excessive androgen production. Objective: The study is aimed to analyze the correlation between the levels of IGFBP-1 and HOMA-IR on Insulin resistance in PCOS. Materials and Methods: A cross-sectional study among 105 PCOS women, including 60 women with Insulin resistance were recruited. The mean of IGFBP-1 and HOMA-IR were 6. 507± 4. 7821 μ g/l and 3. 633± 1. 666 respectively. Results: Low levels of IGFBP-1 were detected in all Insulin resistance women. There was a correlation between HOMA-IR and overweight (p=0. 045), while IGFBP-1 showed no correlation with overweight (p=0. 106). In addition, no correlation between IGFBP-1 with HOMA-IR as a marker of Insulin resistance was detected. Conclusion: Despite the decrease in IGFBP-1, it seems that there is no correlation between IGFBP-1 with HOMA-IR as a marker of Insulin resistance.

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APA: Copy

Firmansyah, Arini, Chalid, Maisuri Tadjuddin, Farid, Retno Budiati, & Abdullah, Nusratuddin. (2018). The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(11), 679-682. SID. https://sid.ir/paper/296470/en

Vancouver: Copy

Firmansyah Arini, Chalid Maisuri Tadjuddin, Farid Retno Budiati, Abdullah Nusratuddin. The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(11):679-682. Available from: https://sid.ir/paper/296470/en

IEEE: Copy

Arini Firmansyah, Maisuri Tadjuddin Chalid, Retno Budiati Farid, and Nusratuddin Abdullah, “The correlation between insulin-like growth factor binding protein 1 (IGFBP-1) and homeostasis model assessment of insulin resistance (HOMA-IR) in polycystic ovarian syndrome with insulin resistance,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 11, pp. 679–682, 2018, [Online]. Available: https://sid.ir/paper/296470/en

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