مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

295
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

135
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study

Pages

  491-496

Abstract

 Background: Tumor protein p53 (TP53) is a tumor suppressor transcriptional regulator protein which plays a critical role in the spermatogenesis. One of the most important regulators of p53 is Murine double minute 2 (MDM2), which acts as a negative regulator of the p53 pathway. Based on the key role of p53 and MDM2 in germ cell Apoptosis, Polymorphisms that cause a change in their function might affect germ cell Apoptosis and the risk of Male infertility. Objective: This study was designed to examine associations of TP53 72 Arg>Pro (rs1042522), and MDM2 309 T>G (rs937283) Polymorphisms with spermatogenetic failure in Iranian population. Materials and Methods: A case-control study was conducted with 150 nonobstructive azoospermia or severe oligozoospermia and 150 fertile controls. The two Polymorphisms, 72 Arg>Pro in TP53 and 309 T>G in MDM2, were genotyped using PCR-RFLP and ARMSPCR respectively. Results: Our analyses revealed that the allele and genotype frequencies of the TP53 R72P polymorphism were not significantly different between the cases and controls (p=0. 41, p=0. 40 respectively). Also, no significant differences were found in the allelic (p=0. 46) and genotypic (p=0. 78) distribution of MDM2 309 T>G polymorphism between patients and controls. Conclusion: The results of this study indicate that Polymorphisms of TP53 and MDM2 genes are unlikely to contribute to the pathogenesis of Male infertility with spermatogenetic failure.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Ebrahim Abadi, Zeinab, KHADEMI BAMI, MARYAM, GOLZADEH, MARYAM, KALANTAR, SEYED MEHDI, & SHEIKHHA, MOHAMMAD HASAN. (2018). The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(8), 491-496. SID. https://sid.ir/paper/296538/en

    Vancouver: Copy

    Ebrahim Abadi Zeinab, KHADEMI BAMI MARYAM, GOLZADEH MARYAM, KALANTAR SEYED MEHDI, SHEIKHHA MOHAMMAD HASAN. The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(8):491-496. Available from: https://sid.ir/paper/296538/en

    IEEE: Copy

    Zeinab Ebrahim Abadi, MARYAM KHADEMI BAMI, MARYAM GOLZADEH, SEYED MEHDI KALANTAR, and MOHAMMAD HASAN SHEIKHHA, “The frequency of TP53 R72P and MDM2 309T>G polymorphisms in Iranian infertile men with spermatogenetic failure: A case-control study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 8, pp. 491–496, 2018, [Online]. Available: https://sid.ir/paper/296538/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button