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Title

TUMOR NECROSIS FACTOR ALPHA -308 G/A SINGLE NUCLEOTIDE POLYMORPHISM AND RISK OF SPERM ABNORMALITIES IN IRANIAN MALES

Pages

  112-116

Abstract

 BackgroundSignaling molecules such as CYTOKINES regulate spermatogenesis during the maturation of germ cells and sperm apoptosis. TUMOR NECROSIS FACTOR ALPHA (TNFα) is one of the most-documented CYTOKINES that is involved in spermatogenesis. We investigated the association of the TNFα -308 G/A single nucleotide POLYMORPHISM with sperm abnormalities in Iranian males.Materials and MethodsThis case-control study included 180 infertile men who re- ferred to Yazd Research and Clinical Center for INFERTILITY and 100 healthy normospermic controls. Infertile men were classified into four groups of azoospermia (n=91), oligospermia (n=26), teratospermia (n=30) and asthenoteratospermia (n=33). After sperm analysis, DNA was extracted from blood and polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) was carried out for the genotyping of TNFα- 308 G/A.ResultsThe A allele was significantly associated with sperm abnormality in our population [(P<0.001, odds ratios (OR) 95% confidence interval (CI)=2.31]. In addition, the A allele was also associated with azoospermia (P<0.001, OR (95% CI)=2.484), oligospermia (P=0.005, OR (95% CI)=2.51) and teratospemia (P<0.001, OR (95% CI)=3.385) but not with asthenoteratospermia (P=0.623).ConclusionOur data suggest that this single nucleotide POLYMORPHISM (SNP) maybe associated with the risk of sperm abnormality in infertile men of Iranian origin.

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    APA: Copy

    KHADEMI BAMI, MARYAM, DEHGHAN TEZERJANI, MASOUD, MONTAZERI, FATEMEH, ASHRAFZADEH MEHRJARDI, HAMID REZA, GHASEMI ESMAILABAD, SAEED, SHEIKHHA, MOHAMMAD HASAN, & KALANTAR, SEYED MEHDI. (2017). TUMOR NECROSIS FACTOR ALPHA -308 G/A SINGLE NUCLEOTIDE POLYMORPHISM AND RISK OF SPERM ABNORMALITIES IN IRANIAN MALES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 11(2), 112-116. SID. https://sid.ir/paper/305926/en

    Vancouver: Copy

    KHADEMI BAMI MARYAM, DEHGHAN TEZERJANI MASOUD, MONTAZERI FATEMEH, ASHRAFZADEH MEHRJARDI HAMID REZA, GHASEMI ESMAILABAD SAEED, SHEIKHHA MOHAMMAD HASAN, KALANTAR SEYED MEHDI. TUMOR NECROSIS FACTOR ALPHA -308 G/A SINGLE NUCLEOTIDE POLYMORPHISM AND RISK OF SPERM ABNORMALITIES IN IRANIAN MALES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2017;11(2):112-116. Available from: https://sid.ir/paper/305926/en

    IEEE: Copy

    MARYAM KHADEMI BAMI, MASOUD DEHGHAN TEZERJANI, FATEMEH MONTAZERI, HAMID REZA ASHRAFZADEH MEHRJARDI, SAEED GHASEMI ESMAILABAD, MOHAMMAD HASAN SHEIKHHA, and SEYED MEHDI KALANTAR, “TUMOR NECROSIS FACTOR ALPHA -308 G/A SINGLE NUCLEOTIDE POLYMORPHISM AND RISK OF SPERM ABNORMALITIES IN IRANIAN MALES,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 11, no. 2, pp. 112–116, 2017, [Online]. Available: https://sid.ir/paper/305926/en

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