The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium

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Mirabutalebi Seyed Hamidreza; Karami Noorodin; MONTAZERI FATEMEH; FESAHAT FARZANEH; SHEIKHHA MOHAMMAD HASAN; Hajimaqsoodi Elnaz; KARIMI ZARCHI MOJGAN; KALANTAR SEYED MEHDI

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Journal: International Journal of Reproductive BioMedicine Year:2018 | Volume:16 | Issue:8 Page(s): 501-506

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Title

The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium

Author(s)

Keywords

Endometriosis

Gene expression

Micro-ribonucleic acid

HOXA10

miR-135a

Abstract

Background: The study of microRNA expression can be effective in the diagnosing and treating different diseases. miR-135a is one of the most important microribonucleic acids involved in Endometriosis. Among the genes that become the target of the miR-135a and are subjected to changes in the endometrium of patients with Endometriosis is HOXA10 gene which is expressed in the endometrium in response to steroid hormones. Objective: The aim of this study was to evaluate the expression of miR-135a and its relationship with the level of HOXA10 Gene expression in both endometrial ectopic and eutopic tissues in patients with Endometriosis compared to the control samples. Materials and Methods: In this prospective case-control study, both case-eutopic and case-ectopic tissue samples were obtained from 17 women with Endometriosis and the eutopic endometrial tissue was sampled from 17 women with normal endometrium as the control group. The gene's expression of miR-135a and HOXA10 were investigated using quantitative reverse transcription PCR (q-RT PCR). Results: A significant decrease in the expression of HOXA10 gene was detected in case-eutopic during the luteal phase compared to the control samples (p=0. 001), while in the case-ectopic, the expression of this gene was increased (p=0. 681) compared to the control samples. In addition, the expression miR-135a in the luteal phase showed a remarkable increase in the case-eutopic endometrial tissue (p=0. 026) as well as a significant decrease in the case-ectopic endometrial tissue compared to the control samples (p=0. 008). Conclusion: Considering the inverse relations between the over-expression of miR-135a and the reduction of HOXA10, it seems that miR-135a may be applied as an endometrial diagnostic and therapeutic biomarker.

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APA: Copy

Mirabutalebi, Seyed Hamidreza, Karami, Noorodin, MONTAZERI, FATEMEH, FESAHAT, FARZANEH, Hajimaqsoodi, Elnaz, KARIMI ZARCHI, MOJGAN, & KALANTAR, SEYED MEHDI. (2018). The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(8), 501-506. SID. https://sid.ir/paper/296540/en

Vancouver: Copy

Mirabutalebi Seyed Hamidreza, Karami Noorodin, MONTAZERI FATEMEH, FESAHAT FARZANEH, Hajimaqsoodi Elnaz, KARIMI ZARCHI MOJGAN, KALANTAR SEYED MEHDI. The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(8):501-506. Available from: https://sid.ir/paper/296540/en

IEEE: Copy

Seyed Hamidreza Mirabutalebi, Noorodin Karami, FATEMEH MONTAZERI, FARZANEH FESAHAT, Elnaz Hajimaqsoodi, MOJGAN KARIMI ZARCHI, and SEYED MEHDI KALANTAR, “The relationship between the expression levels of miR-135a and HOXA10 gene in the eutopic and ectopic endometrium,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 8, pp. 501–506, 2018, [Online]. Available: https://sid.ir/paper/296540/en

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