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Information Journal Paper

Title

Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT

Pages

  299-304

Abstract

 Background: Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium. Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of Assisted reproductive technology cycle in patients with repeated implantation failures. Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic sperm injection-embryo transfer failures. All patients were stimulated with standard long protocol. All embryos were transferred on day five in blastocyst stage in both groups. The treated group received 300 μ g (0. 5 ml) recombinant human G-CSF subcutaneously which was injected 30 min before blastocyst embryo transfer. Results: There was not statistically significant differences in abortion rate in G-CSF and control group (p=0. 09). G-CSF treated group showed higher clinical pregnancy rate in comparison with control group (56. 2% vs. 40. 0%) but it was not statistically significant (p=0. 09). Although live birth rate in G-CSF group was higher than control group (53. 1% vs. 35. 0%) but there wasn’ t statistically significant difference in the overall live birth rate between the two groups (p=0. 10). G-CSF group had a twin pregnancies while in control group there was no twin pregnancy. Conclusion: Our result demonstrates the possibility that pregnancy outcome is better in women with repeated unexplained In vitro fertilization failure who are treated with G-CSF.

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    APA: Copy

    AREFI, SOHEILA, FAZELI, ELHAM, Esfahani, Manijeh, BORHANI, NASIM, YAMINI, NAZILA, HOSSEINI, AHMAD, & FARIFTEH, FATTANEH. (2018). Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(5), 299-304. SID. https://sid.ir/paper/296556/en

    Vancouver: Copy

    AREFI SOHEILA, FAZELI ELHAM, Esfahani Manijeh, BORHANI NASIM, YAMINI NAZILA, HOSSEINI AHMAD, FARIFTEH FATTANEH. Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(5):299-304. Available from: https://sid.ir/paper/296556/en

    IEEE: Copy

    SOHEILA AREFI, ELHAM FAZELI, Manijeh Esfahani, NASIM BORHANI, NAZILA YAMINI, AHMAD HOSSEINI, and FATTANEH FARIFTEH, “Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 5, pp. 299–304, 2018, [Online]. Available: https://sid.ir/paper/296556/en

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