Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

322
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

105
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Troxerutin protect sperm, seminiferous epithelium and pituitary-gonadal axis from torsion-detorsion injury: An experimental study

Pages

  315-322

Abstract

 Background: Troxerutin is a flavonoid antioxidant that protect different organ against damage caused by ischemia-reperfusion. Objective: The aim of this study was to evaluate the effect of Troxerutin in reducing the damages caused by ischemia-reperfusion in rat's Testis. Materials and Methods: 40 Male Wistar rats (2 month old) were divide to four groups (n=10). Group1 (sham), Group 2 (control, ischemia-reperfusion (I/R) without treatment), Group 3 (I/R+150 mg/kg of Troxerutin), and group 4 (I/R+20 mg/kg of vitamin C). Treatment of group 3 and group 4 during Torsion (twists 720 counter clock at 90 min) followed by 50 days deTorsion. After 50 days, blood samples were collected and rats in all study groups were killed and their testes were removed, and fixed with Bouin’ s solution. Testis was stained with hematoxylin and eosin dye and the level of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were measured with ELISEA methods. TUNEL was employed to detect apoptosis. Epididymis caudal part was removed and total sperm count was determined. Johnson techniques were used for assessment of seminiferous tubules quality. Results: Troxerutin treated group has higher Johnson score’ s (p≤ 0. 001), antiapoptotic properties (p≤ 0. 001), sperm count (p=0. 065), and higher LH (p≤ 0. 001), FSH (p≤ 0. 001) and testosterone (p=0. 002) levels than control group. Vitamin C treated group showed increase level of testosterone but didn’ t show significant differences on the number of apoptotic cells, Johnson scores, LH, FSH and sperm count than control group. Conclusion: Troxerutin has protective effects on testicular Torsion induced injury and can ameliorate Spermatogenesis in the Torsion-deTorsion models.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Kheirollahi, Abdolreza, ABBASZADEH, ABOLFAZL, ANBARI, KHATEREH, Rostami, Behrouz, Ahangari, Amirhossein, HASSANVAND, AFSHIN, & GHOLAMI, MOHAMMADREZA. (2018). Troxerutin protect sperm, seminiferous epithelium and pituitary-gonadal axis from torsion-detorsion injury: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(5), 315-322. SID. https://sid.ir/paper/296559/en

    Vancouver: Copy

    Kheirollahi Abdolreza, ABBASZADEH ABOLFAZL, ANBARI KHATEREH, Rostami Behrouz, Ahangari Amirhossein, HASSANVAND AFSHIN, GHOLAMI MOHAMMADREZA. Troxerutin protect sperm, seminiferous epithelium and pituitary-gonadal axis from torsion-detorsion injury: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(5):315-322. Available from: https://sid.ir/paper/296559/en

    IEEE: Copy

    Abdolreza Kheirollahi, ABOLFAZL ABBASZADEH, KHATEREH ANBARI, Behrouz Rostami, Amirhossein Ahangari, AFSHIN HASSANVAND, and MOHAMMADREZA GHOLAMI, “Troxerutin protect sperm, seminiferous epithelium and pituitary-gonadal axis from torsion-detorsion injury: An experimental study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 5, pp. 315–322, 2018, [Online]. Available: https://sid.ir/paper/296559/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top