Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

480
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

211
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

PROTECTIVE EFFECTS OF RUTIN AND NARINGIN IN TESTICULAR ISCHEMIA- REPERFUSION INDUCED OXIDATIVE STRESS IN RATS

Pages

  209-214

Abstract

 Introduction: TESTICULAR TORSION and detorsion causes REPERFUSION injury which damages the testicular tissue and affects the quality of sperm. Deterioration in the quality of sperm worldwide is the recent scenario and one of its reasons is testicular ischemic/ REPERFUSION (IR) injury. Therefore the present study aims at producing new drugs for the treatment of testicular IR injury.Methods: 42 animals were selected for the study and divided into 7 groups, each containing 6 rats. Bioflavonoids were tested for their efficacy in reversing the damage done to the testicular tissue by causing TESTICULAR TORSION and detorsion in rats. As oxidative stress produced in the above condition causes tissue damage, MDA level was measured and antioxidant enzymes SOD and catalse were evaluated. Histological examination was conducted to find the extent of damage and the protective effect of RUTIN and NARINGIN. One-way ANOVA and Tukey’s post-hoc test were used for data analysis. A p-value<0.001 was considered statistically significant.Results: MDA levels increased and antioxidant enzymes decreased drastically in the group of rats with TESTICULAR TORSION and detorsion which clearly indicates a rise in oxidative stress (68% rise in the case of MDA and 20% and 16% decrease in SOD and catalase concentrations, respectively). RUTIN and NARINGIN-treated groups showed the beneficial effects of the medicinal drugs, particularly in higher doses. RUTIN, 10 mg/kg, was effective when compared to NARINGIN in providing protection. Compared to the animals in the control group, there was a 30% reduction in MDA levels and a 20% increment in SOD levels plus a five-fold increase in catalse in the RUTIN-treated group (10 mg/kg). Histological examination supported the above claims.Conclusion: Oxidative stress in testicular injury affects the quality of sperm. RUTIN and NARINGIN in higher doses protected testicular tissue effectively. Further studies in this direction may prove beneficial.

Cites

References

Cite

APA: Copy

BUTCHI, RAJU AKONDI, CHALLA, SIVA REDDY, & AKULA, ANNAPURNA. (2011). PROTECTIVE EFFECTS OF RUTIN AND NARINGIN IN TESTICULAR ISCHEMIA- REPERFUSION INDUCED OXIDATIVE STRESS IN RATS. JOURNAL OF REPRODUCTION AND INFERTILITY, 12(3 (48)), 209-214. SID. https://sid.ir/paper/569610/en

Vancouver: Copy

BUTCHI RAJU AKONDI, CHALLA SIVA REDDY, AKULA ANNAPURNA. PROTECTIVE EFFECTS OF RUTIN AND NARINGIN IN TESTICULAR ISCHEMIA- REPERFUSION INDUCED OXIDATIVE STRESS IN RATS. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2011;12(3 (48)):209-214. Available from: https://sid.ir/paper/569610/en

IEEE: Copy

RAJU AKONDI BUTCHI, SIVA REDDY CHALLA, and ANNAPURNA AKULA, “PROTECTIVE EFFECTS OF RUTIN AND NARINGIN IN TESTICULAR ISCHEMIA- REPERFUSION INDUCED OXIDATIVE STRESS IN RATS,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 12, no. 3 (48), pp. 209–214, 2011, [Online]. Available: https://sid.ir/paper/569610/en

Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top