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Information Journal Paper

Title

Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study

Pages

  489-494

Abstract

 Background: Higher Fetuin-A (FA) concentrations were found to be associated with obesity and there is an interest to the relation between maternal FA and Pregnancy outcomes. Objective: In this study, our aim was to evaluate the association of maternal plasma levels of FA with Fetal growth restriction (FGR). Materials and Methods: 41 pregnant women with FGR and 40 controls were recruited in this case-control study between July and November 2015. At the diagnosis of FGR, venous blood samples (10 cc) were obtained for FA analysis. Results: Maternal plasma FA levels were significantly higher in fetal growth-restricted pregnant women compared with controls (19. 3 ± 3. 0 ng/ml vs 25. 9 ± 6. 8 ng/ml, p = 0. 001). Area under receiver operating characteristic curve analysis of FA in FGR was 0. 815 (95% confidence interval (CI): 0. 718-0. 912, p < 0. 001). The maternal FA levels with values more than 22. 5 ng/ml had a sensitivity of about 73. 17% (95% CI: 56. 79-85. 25) and a specificity of about 82. 5% (95% CI: 66. 64-92. 11) with positive and negative predictive values of about 81. 08% (95% CI: 64. 29-91. 45) and 75% (95% CI: 59. 35-86. 30), respectively. Therefore, the diagnostic accuracy was obtained about 77. 78%. Conclusion: The results of this study show higher maternal plasma levels of FA in FGR. Further studies are needed in order to demonstrate the long-term effects of FA in pregnancies complicated with FGR and early prediction of FGR.

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    APA: Copy

    Ibanoglu, Mujde Can, Sanhal, Cem Yasar, Ozgu Erdinc, Seval, Kara, Ozgur, Yucel, Aykan, & Uygur, Dilek. (2019). Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(7), 489-494. SID. https://sid.ir/paper/296578/en

    Vancouver: Copy

    Ibanoglu Mujde Can, Sanhal Cem Yasar, Ozgu Erdinc Seval, Kara Ozgur, Yucel Aykan, Uygur Dilek. Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(7):489-494. Available from: https://sid.ir/paper/296578/en

    IEEE: Copy

    Mujde Can Ibanoglu, Cem Yasar Sanhal, Seval Ozgu Erdinc, Ozgur Kara, Aykan Yucel, and Dilek Uygur, “Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 7, pp. 489–494, 2019, [Online]. Available: https://sid.ir/paper/296578/en

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