Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: An experimental study

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SAMPANNANG APICHAKAN; ARUN SUPATCHAREE; BURAWAT JATURON; SUKHORUM WANNISA; IAMSAARD SITTHICHAI

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Journal: International Journal of Reproductive BioMedicine Year:2019 | Volume:17 | Issue:8 Page(s): 567-576

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Title

Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: An experimental study

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Keywords

Diabetes mellitus

Testicular phosphorylated protein

Steroidogenic acute regulatory protein

Streptozotocin

Mice

Abstract

Background: Types 1 and 2 Diabetes mellitus (DM) are known to be the cause of sub/infertility. However, the comparisons of potential markers in spermatogenesis and steroidogenesis in DM males have never been elucidated. Objective: This study aimed to examine the expressions of tyrosine-phosphorylated and steroidogenic acute regulatory (StAR) proteins in testis of DM Mice. Materials and Methods: Fifty-six male C57BL/6 Mice were divided into four groups (n = 14/ each): control of MLD-STZ (multiple low doses of Streptozotocin), MLD-STZ, control of HFD-STZ (high-fat diet with STZ), and HFD-STZ. MLD-STZ Mice (type 1 DM) were intraperitoneally (i. p. ) injected with STZ at 40 mg/kg BW for five days. HFD-STZ Mice (type 2 DM) received an HFD for 14 days and i. p.-induced by STZ at 85 mg/kg BW and fed with HFD. At the end of the experiment (days 36 and 72), the expressions of phosphorylated proteins and StAR were examined. Results: Tyrosine phosphorylated proteins were localized in late spermatids, luminal fluid, and Leydig cells. The intensities of phosphorylated 110, 85, 72, 60, and 55 kDas were lower in the 36 day-DM Mice. Although such intensities were present in both groups, only 85 kDa in the MLD-STZ Mice was higher in HFD Mice at 72 days. StAR expressions in both groups were decreased than that of the controls. Conclusion: Decreased expressions of StAR and tyrosine-phosphorylated proteins may be directly involved in low testosterone levels and impaired spermatogenesis. These findings support the notion that both DM types play a role in male infertility.

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APA: Copy

SAMPANNANG, APICHAKAN, ARUN, SUPATCHAREE, BURAWAT, JATURON, SUKHORUM, WANNISA, & IAMSAARD, SITTHICHAI. (2019). Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(8), 567-576. SID. https://sid.ir/paper/296587/en

Vancouver: Copy

SAMPANNANG APICHAKAN, ARUN SUPATCHAREE, BURAWAT JATURON, SUKHORUM WANNISA, IAMSAARD SITTHICHAI. Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(8):567-576. Available from: https://sid.ir/paper/296587/en

IEEE: Copy

APICHAKAN SAMPANNANG, SUPATCHAREE ARUN, JATURON BURAWAT, WANNISA SUKHORUM, and SITTHICHAI IAMSAARD, “Expression of testicular phosphorylated proteins in types 1 and 2 diabetes mellitus in mice: An experimental study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 8, pp. 567–576, 2019, [Online]. Available: https://sid.ir/paper/296587/en

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