Ameliorative effects of crocin on paraquat-induced oxidative stress in testis of adult mice: An experimental study

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Kamali Fahime Sadat; SHAHROOZ RASOUL; NAJAFI GOLAMREZA; RAZI MAZDAK

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Journal: International Journal of Reproductive BioMedicine Year:2019 | Volume:17 | Issue:11 Page(s): 807-818

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Title

Ameliorative effects of crocin on paraquat-induced oxidative stress in testis of adult mice: An experimental study

Author(s)

Kamali Fahime Sadat | SHAHROOZ RASOUL | NAJAFI GOLAMREZA | RAZI MAZDAK | Issue Writer Certificate

Keywords

Histology

Testis

Paraquat

Crocin

Mice

Abstract

Background: Paraquat (PQ), as a pyridine compound, is widely used worldwide to control annual weeds. The oxidative stress caused by PQ can cause deleterious changes in the testicular tissue. Objective: An investigation on the protective effects of Crocin (CCN) against PQinduced oxidative damages and apoptotic indices in testicular tissue. Materials and Methods: Twenty-eight adult male albino Mice (20-25 gr) were divided into four groups (n = 7/each). The control group received 0. 1 ml/day of normal saline by intraperitoneal injection (IP); sham-control group received PQ 5 mg/kg/day, IP, and the experimental groups received PQ (CCN+PQ) and CCN-sole (200 mg/kg/day, IP), respectively, for 35 continuous days. At the end of the treatment period, the testes were dissected out and used for biochemical, molecular, and histological analyses. The expressions of tumor suppressor p53, B-cell lymphoma 2 (bcl-2), and caspase-3 were considered as hallmark factors of mitochondria-dependent apoptosis. Moreover, the testicular superoxide dismutase (SOD) and malondialdehyde (MDA) were evaluated as key biomarkers for oxidative stress. Results: The PQ significantly (p < 0. 02, p < 0. 01) diminished the spermatogenesis indices and SOD, increased MDA levels, and enhanced the apoptosis-related gene expression. However, the co-administration of CCN and PQ significantly (p < 0. 01, p < 0. 01, p < 0. 02) ameliorated the spermatogenesis ratio, upregulated the SOD level as well as bcl-2 expression, and reduced the MDA content and apoptosis vs the PQ-sole group. Conclusion: This study showed that the antioxidant properties of CCN enable to ameliorate the PQ-induced destructive effects by upregulating the testicular structure, antioxidant and apoptotic status.

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APA: Copy

Kamali, Fahime Sadat, SHAHROOZ, RASOUL, NAJAFI, GOLAMREZA, & RAZI, MAZDAK. (2019). Ameliorative effects of crocin on paraquat-induced oxidative stress in testis of adult mice: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(11), 807-818. SID. https://sid.ir/paper/296615/en

Vancouver: Copy

Kamali Fahime Sadat, SHAHROOZ RASOUL, NAJAFI GOLAMREZA, RAZI MAZDAK. Ameliorative effects of crocin on paraquat-induced oxidative stress in testis of adult mice: An experimental study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(11):807-818. Available from: https://sid.ir/paper/296615/en

IEEE: Copy

Fahime Sadat Kamali, RASOUL SHAHROOZ, GOLAMREZA NAJAFI, and MAZDAK RAZI, “Ameliorative effects of crocin on paraquat-induced oxidative stress in testis of adult mice: An experimental study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 11, pp. 807–818, 2019, [Online]. Available: https://sid.ir/paper/296615/en

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