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Information Journal Paper

Title

Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

Author(s)

 Najib Fatemeh Sadat | POORDAST TAHEREH | Rezvan Nia Mina | DABBAGHMANESH MOHAMMAD HOSSEIN | Issue Writer Certificate 

Pages

  57-64

Abstract

 Background: There is limited evidence about the anti-diabetic effects of Selenium supplementation in women with Gestational Diabetes mellitus (GDM). Objective: This study investigates the effects of Selenium supplementation on glucose homeostasis in women with GDM. Materials and Methods: A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100μ g Selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention. Results: The mean maternal age of the patients who took Selenium supplements was 29. 19 ± 6. 16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ± 4. 43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the Selenium group at the end of study (p = 0. 25, p = 0. 87, p = 0. 34, p = 0. 57, and p = 0. 31, respectively). Conclusion: The results of this trial suggest that supplementation with 100μ g of Selenium does not modulate glucose homeostasis in women with GDM.

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    APA: Copy

    Najib, Fatemeh Sadat, POORDAST, TAHEREH, Rezvan Nia, Mina, & DABBAGHMANESH, MOHAMMAD HOSSEIN. (2020). Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 18(1), 57-64. SID. https://sid.ir/paper/296629/en

    Vancouver: Copy

    Najib Fatemeh Sadat, POORDAST TAHEREH, Rezvan Nia Mina, DABBAGHMANESH MOHAMMAD HOSSEIN. Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2020;18(1):57-64. Available from: https://sid.ir/paper/296629/en

    IEEE: Copy

    Fatemeh Sadat Najib, TAHEREH POORDAST, Mina Rezvan Nia, and MOHAMMAD HOSSEIN DABBAGHMANESH, “Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 18, no. 1, pp. 57–64, 2020, [Online]. Available: https://sid.ir/paper/296629/en

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