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Information Journal Paper

Title

THE ROLE OF IMMUNE SYSTEM IN IDIOPATHIC ANTERIOR UVEITIS

Pages

  91-94

Abstract

 Background: Idiopathic anterior uveitis is a form of anterior segment inflammation in which a detailed medical history, general and ocular physical examination, is not associated with any defined clinical syndrome. Alterations in immune system parameters have been reported in patients with idiopathic posterior uveitis, however no study has been performed to evaluate the role of immune system parameters in patients with idiopathic anterior uveitis. In this study the immune system function in patients with idiopathic anterior uveitis was evaluated.Objective: To evaluate the immune system function in patients with idiopathic non-infectious anterior uveitis. Methods: 51 patients with anterior uveitis, 32 women (62.7%) and 19 men (37.3%), participated in this study. Intensity of intraocular inflammation was scored according to standard uveitis grading system. In all cases, serum levels of immunoglobulins A, G, M and E, C3 and C4 complement components, and autoantibodies against ds- DNA and ACLA, were measured using ELISA method.Results: 49 patients out of 51 (96%) showed altered serum levels of immunological parameters, compared to the normal values. Changes in serum immunoglobulin concentration were present in 44 patients, with increased IGA levels being the most common. Serum values of C3 and C4 complement proteins were also increased in 29 subjects. Ds-DNA autoantibody was positive in 15 cases and equivocal in 19 cases. ACLA was positive and equivocal in 3 and 9 patients, respectively. Conclusion: Immune abnormalities found in serum of 49 patients with idiopathic anterior uveitis may play a role in the pathogenesis of idiopathic anterior uveitis.    

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    APA: Copy

    RAHIMI, M., & NAJAFI, M.. (2006). THE ROLE OF IMMUNE SYSTEM IN IDIOPATHIC ANTERIOR UVEITIS. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 3(2), 91-94. SID. https://sid.ir/paper/296752/en

    Vancouver: Copy

    RAHIMI M., NAJAFI M.. THE ROLE OF IMMUNE SYSTEM IN IDIOPATHIC ANTERIOR UVEITIS. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2006;3(2):91-94. Available from: https://sid.ir/paper/296752/en

    IEEE: Copy

    M. RAHIMI, and M. NAJAFI, “THE ROLE OF IMMUNE SYSTEM IN IDIOPATHIC ANTERIOR UVEITIS,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 3, no. 2, pp. 91–94, 2006, [Online]. Available: https://sid.ir/paper/296752/en

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