IMMUNOPHENOTYPIC SUBTYPING OF LEUKEMIC CELLS FROM IRANIAN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA: ASSOCIATION TO DISEASE OUTCOME

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ASGARIAN OMRAN H.; SHABANI M.; SHAHRESTANI T.; SARAFNEZHAD A.; KHOSHNOUDI J.; SHOKRI F.; VOSOUGH PARVANEH; FARANOUSH M.; SHARIFIAN R.A.; JEDI TEHRANI MAHMOUD; RABANI H.

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Journal: Iranian Journal of Immunology Year:2007 | Volume:4 | Issue:1 Page(s): 15-25

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Title

IMMUNOPHENOTYPIC SUBTYPING OF LEUKEMIC CELLS FROM IRANIAN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA: ASSOCIATION TO DISEASE OUTCOME

Author(s)

Keywords

IMMUNOPHENOTYPING

ALL

PRO-B

PRE-B

FLOW CYTOMETRY

Abstract

Background: Immunophenotypic characterization of the leukemic cells has been widely used as a tool for diagnosis, classification, stratification, and determination of prognosis of leukemia. Objective: To investigate the immunophenotypic subtypes of Iranian patients with Acute Lymphoblastic Leukemia (ALL) and its association with disease outcome. Methods: In this study, a total of 60 Iranian patients with ALL were immunophenotyped by FLOW CYTOMETRY using a panel of monoclonal antibodies specific for CD2, CD3, CD5, CD10, CD13, CD14, CD19, CD20, CD33, CD34, CD45, HLA-DR, and TdT molecules. Results: Samples were initially categorized into T-ALL (n=9), B-ALL (n=50), and mixed lineage (n=1) based on the expression patterns of CD3 and CD19 molecules. B-ALL patients were further classified into four subtypes, including PRO-B (11.7%), PRE-B I (46.7%), PRE-B II (21.7%), and immature/ mature B cells (3.3%) on the basis of expression of CD10, CD19, CD20, HLA-DR, and TdT. Clinical manifestations and laboratory findings of the patients did not reveal any association with imunophenotypic subtypes of ALL, with the exception of mediastinal mass and WBC count at the time of diagnosis which were found to be significantly higher in patients with T-ALL compared with B-ALL (P=0.001 and 0.014, respectively). Follow up of these patients showed that the frequency of relapses in T-ALL is greater than B-ALL. Conclusion: Our results indicate that overall immunophenotypic profile of Iranian ALL patients is similar to previous reports and it might be used for monitoring the minimal residual disease, evaluation of treatment, and prediction of disease outcome.

Cites

EFFECTS OF L-ASPARGINASE ADMINISTRATION ON ANTICOAGULANT PROTEINS AND PLATELET FUNCTION IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA

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APA: Copy

ASGARIAN OMRAN, H., SHABANI, M., SHAHRESTANI, T., SARAFNEZHAD, A., KHOSHNOUDI, J., SHOKRI, F., VOSOUGH, PARVANEH, FARANOUSH, M., SHARIFIAN, R.A., JEDI TEHRANI, MAHMOUD, & RABANI, H.. (2007). IMMUNOPHENOTYPIC SUBTYPING OF LEUKEMIC CELLS FROM IRANIAN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA: ASSOCIATION TO DISEASE OUTCOME. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 4(1), 15-25. SID. https://sid.ir/paper/296764/en

Vancouver: Copy

ASGARIAN OMRAN H., SHABANI M., SHAHRESTANI T., SARAFNEZHAD A., KHOSHNOUDI J., SHOKRI F., VOSOUGH PARVANEH, FARANOUSH M., SHARIFIAN R.A., JEDI TEHRANI MAHMOUD, RABANI H.. IMMUNOPHENOTYPIC SUBTYPING OF LEUKEMIC CELLS FROM IRANIAN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA: ASSOCIATION TO DISEASE OUTCOME. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2007;4(1):15-25. Available from: https://sid.ir/paper/296764/en

IEEE: Copy

H. ASGARIAN OMRAN, M. SHABANI, T. SHAHRESTANI, A. SARAFNEZHAD, J. KHOSHNOUDI, F. SHOKRI, PARVANEH VOSOUGH, M. FARANOUSH, R.A. SHARIFIAN, MAHMOUD JEDI TEHRANI, and H. RABANI, “IMMUNOPHENOTYPIC SUBTYPING OF LEUKEMIC CELLS FROM IRANIAN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA: ASSOCIATION TO DISEASE OUTCOME,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 4, no. 1, pp. 15–25, 2007, [Online]. Available: https://sid.ir/paper/296764/en

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