مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

348
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

193
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

IMMUNOGENICITY OF A TRIPLE DIPHTHERIA-TETANUS- WHOLE CELL PERTUSSIS VACCINE IN IRANIAN PRESCHOOL CHILDREN

Pages

  101-109

Abstract

 Background: IMMUNIZATION against diphtheria, tetanus and pertussis has been applied in Iran since 1950. WHO suggests periodical evaluation of effectiveness of the triple diphtheria-tetanus-whole cell pertussis (DTwP) vaccine, worldwide. Objective(s): To determine the immunogenicity of locally manufactured DTwP vaccine administered to preschool children in a number of health centers of Tehran in 2006. Method(s): In this prospective study, 350 children aged 4-6 years were injected with DTwP vaccine manufactured by Razi Institute of Iran. Blood samples were collected before and 2-4 weeks after the vaccination. The immunogenicity of the vaccine was assayed by measurement of specific antibodies using enzyme-linked immunosorbent assay (ELISA) technique.Results: Of the 337 children who were vaccinated, 99.4% and 100% had protective anti-diphtheria and anti-tetanus antibody titers, respectively. The vaccine response and seroconversion for pertussis was achieved in 70.3% of the subjects. The geometric mean titers (GMT) of the antibodies produced against diphtheria, tetanus and pertussis by DTwP vaccine were 7.76, 9.37 IU/ml and 30.20 EU/ml after booster vaccine dose, respectively.Conclusion(s): Comparison of the results obtained from this study with those of previous work performed in other countries reveals that immunogenicity of diphtheria and tetanus components is similar to other vaccines, but the immunogenicity of pertussis vaccine was less efficient. The lower immunogenicity of DTwP against pertussis may be related to the bacterial strain used or the formulation protocol adopted for the vaccine preparation.  

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    ZAREI, S., JEDI TEHRANI, MAHMOUD, AKHOND, M., ZERAATI, H.A., KHEIRKHAH, T., GHAZANFARI, M., & SHOKRI, F.. (2007). IMMUNOGENICITY OF A TRIPLE DIPHTHERIA-TETANUS- WHOLE CELL PERTUSSIS VACCINE IN IRANIAN PRESCHOOL CHILDREN. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 4(2), 101-109. SID. https://sid.ir/paper/296777/en

    Vancouver: Copy

    ZAREI S., JEDI TEHRANI MAHMOUD, AKHOND M., ZERAATI H.A., KHEIRKHAH T., GHAZANFARI M., SHOKRI F.. IMMUNOGENICITY OF A TRIPLE DIPHTHERIA-TETANUS- WHOLE CELL PERTUSSIS VACCINE IN IRANIAN PRESCHOOL CHILDREN. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2007;4(2):101-109. Available from: https://sid.ir/paper/296777/en

    IEEE: Copy

    S. ZAREI, MAHMOUD JEDI TEHRANI, M. AKHOND, H.A. ZERAATI, T. KHEIRKHAH, M. GHAZANFARI, and F. SHOKRI, “IMMUNOGENICITY OF A TRIPLE DIPHTHERIA-TETANUS- WHOLE CELL PERTUSSIS VACCINE IN IRANIAN PRESCHOOL CHILDREN,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 4, no. 2, pp. 101–109, 2007, [Online]. Available: https://sid.ir/paper/296777/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button