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Information Journal Paper

Title

ASSOCIATION BETWEEN HLA-DRB1*01 AND HLA-CW*08 AND OUTCOME FOLLOWING HTLV-I INFECTION

Pages

  94-100

Keywords

HLA 

Abstract

 Background: Human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory disease which occurs in less than 2% of HTLV-I -infected individuals. High proviral load, high HTLV-I-specific CD8+ cytotoxic T lymphocyte frequency (CTL) and host genetic factors such as HLA all appear to be associated with HTLV-I infection. Previous studies have shown that HLA-DRB1*01 increases the risk of HAM/TSP in Japanese HTLV-I infected individuals. Objective: To investigates the association between HLA class II DRB1 alleles and HLA class I alleles (HLA-Cw*08, B54, A*02 and A-30) in HTLV-I infected individuals in Mashhad. Methods: Here we determined the frequency of HLA class II DRB1, using INNO-LIPA reverse hybridization line probe assay, and HLA class I alleles (HLA-Cw*08,B54, A*02 and A-30) by PCR-SSCP method in healthy controls, HAM/TSP patients and HTLV-I infected individuals born and resident in Mashhad. Results: The frequency of HLA-DRB1*01 alleles in this population was different from other areas of Iran. The frequency of HLA-DRB1*01 was significantly increased in HAM/TSP patients compared with carriers (p 0.028; OR=9.4). The frequency of HLACw* 08 was also significantly increased in HAM/TSP patients compared with controls (p=0.03; OR=13.5). Conclusion: Our results may suggest that possession of HLADRB1* 01 increases the risk of HAM/TSP in HTLV-I-infected individuals and HLACw* 08 correlates with low CTL immune response in HAM/TSP patients.

Cites

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    APA: Copy

    RAFATPANAH, H., PRAVICA, V., FARID HOSSINI, R., TABATABAEI, A., OLLIER, W., POULTON, K., THOMSON, W., & HUTCHINSON, I.. (2007). ASSOCIATION BETWEEN HLA-DRB1*01 AND HLA-CW*08 AND OUTCOME FOLLOWING HTLV-I INFECTION. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 4(2), 94-100. SID. https://sid.ir/paper/296782/en

    Vancouver: Copy

    RAFATPANAH H., PRAVICA V., FARID HOSSINI R., TABATABAEI A., OLLIER W., POULTON K., THOMSON W., HUTCHINSON I.. ASSOCIATION BETWEEN HLA-DRB1*01 AND HLA-CW*08 AND OUTCOME FOLLOWING HTLV-I INFECTION. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2007;4(2):94-100. Available from: https://sid.ir/paper/296782/en

    IEEE: Copy

    H. RAFATPANAH, V. PRAVICA, R. FARID HOSSINI, A. TABATABAEI, W. OLLIER, K. POULTON, W. THOMSON, and I. HUTCHINSON, “ASSOCIATION BETWEEN HLA-DRB1*01 AND HLA-CW*08 AND OUTCOME FOLLOWING HTLV-I INFECTION,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 4, no. 2, pp. 94–100, 2007, [Online]. Available: https://sid.ir/paper/296782/en

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