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Information Journal Paper

Title

A FUNCTIONAL POLYMORPHISM OF THE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR IS NOT ASSOCIATED WITH THE OUTCOME OF HTLV-I INFECTION

Pages

  40-47

Abstract

 Introduction: Genetic background has known to be associated with the outcome of human T cell lymphotropic virus (HTLV) type I infection. In The present study we investigate the association between GM-CSF GENE POLYMORPHISMS with the outcome of HTLV-I infection.Materials and Methods: We analyzed 3 single-nucleotide polymorphisms in the promter region of granulocyte macrophage colony stimulating factor (GM-CSF) at positions -677*A/C, -1440*A/G and -1916*T/C in 68 patients with HTLVI– associated myelopathy/tropical spastic paraparesis (HAM/TSP) and 77 HTLV-I-seropositive asymptomatic carriers and 175 healthy controls from an area in Iran, Mashhad, where HTLV-I is endemic. Results: No significant differences were observed in the distribution of GM-CSF polymorphisms between HAM/TSP patients, HTLV-I carriers and healthy controls (P> 0.05). The -677*A/C polymorphism fall within the transcriptional enhancer factor-2 (TEF-2) binding site, so an ELECTROPHORETIC MOBILITY SHIFT ASSAY (EMSA) was performed to determine the effects of polymorphisms on protein binding to the GM-CSF promoter. The result showed a significantly higher binding efficiency of nuclear protein to the A allele compared with the C allele.Conclusion: Our study suggests that polymorphisms in the GM-CSF promoter is not associated with the outcome of HTLV-I infection, however, GM-CSF polymorphism at position -677 could indeed influence gene expression.

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    APA: Copy

    SHIRDEL, A., RAFATPANAH, H., RAHIMI, HASAN, REZAEI, A.A.R., AZARPAZHOUH, M.R., BEYK YAZDI, A., & HUTCHINSON, I.V.. (2010). A FUNCTIONAL POLYMORPHISM OF THE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR IS NOT ASSOCIATED WITH THE OUTCOME OF HTLV-I INFECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 13(2 (45)), 40-47. SID. https://sid.ir/paper/558462/en

    Vancouver: Copy

    SHIRDEL A., RAFATPANAH H., RAHIMI HASAN, REZAEI A.A.R., AZARPAZHOUH M.R., BEYK YAZDI A., HUTCHINSON I.V.. A FUNCTIONAL POLYMORPHISM OF THE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR IS NOT ASSOCIATED WITH THE OUTCOME OF HTLV-I INFECTION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2010;13(2 (45)):40-47. Available from: https://sid.ir/paper/558462/en

    IEEE: Copy

    A. SHIRDEL, H. RAFATPANAH, HASAN RAHIMI, A.A.R. REZAEI, M.R. AZARPAZHOUH, A. BEYK YAZDI, and I.V. HUTCHINSON, “A FUNCTIONAL POLYMORPHISM OF THE GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR IS NOT ASSOCIATED WITH THE OUTCOME OF HTLV-I INFECTION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 13, no. 2 (45), pp. 40–47, 2010, [Online]. Available: https://sid.ir/paper/558462/en

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