مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

PRODUCTION AND CHARACTERIZATION OF A MONOCLONAL ANTIBODY AGAINST AN ANTIGEN ON THE SURFACE OF NON-SMALL CELL CARCINOMA OF THE LUNG

Pages

  206-214

Keywords

Abstract

 Background: Lung carcinoma is a multiple type cancer comprising of small cell and non-small cell carcinomas (NSCLC). For therapeutic and diagnostic purposes, serum monoclonal antibodies have been produced against lung cancer. Objective: To charac-terize a murine monoclonal antibody (ME3D11) reactive with human NSCLC. Methods: A murine monoclonal antibody (ME3D11) reactive with human NSCLC was selected after immunization of BALB/c mice with a human large cell carcinoma with neuroen-docrine differentiation, and was tested by immunofloursence staining and Western blot analysis. Results: Our study showed that the antigen recognized by ME3D11 antibody was a cell surface antigen of 170kDa. This antigen is expressed on the cell surface of all NSCLC and a few carcinoma cell lines. In contrast, this antigen is neither expressed on the cell surface of human sarcoma, nor on the hematopoietic and normal cell lines. This anti-body had no effect on spontaneous proliferation of MEHR-80 cell line in vitro.Conclusion: High degree of binding of this monoclonal antibody to NSCLC and some other carci-noma cells warrants further studies on its potential use in diagnosis and therapy of can-cer by conjugation to drugs, toxins or radionuclides.

Cites

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    • Cite

    APA: Copy

    SHARIFZADEH, S., MOJTAHEDI, H., JEDI TEHRANI, MAHMOUD, BAYAT, A., & GHADERI, A.. (2007). PRODUCTION AND CHARACTERIZATION OF A MONOCLONAL ANTIBODY AGAINST AN ANTIGEN ON THE SURFACE OF NON-SMALL CELL CARCINOMA OF THE LUNG. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 4(4), 206-214. SID. https://sid.ir/paper/296798/en

    Vancouver: Copy

    SHARIFZADEH S., MOJTAHEDI H., JEDI TEHRANI MAHMOUD, BAYAT A., GHADERI A.. PRODUCTION AND CHARACTERIZATION OF A MONOCLONAL ANTIBODY AGAINST AN ANTIGEN ON THE SURFACE OF NON-SMALL CELL CARCINOMA OF THE LUNG. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2007;4(4):206-214. Available from: https://sid.ir/paper/296798/en

    IEEE: Copy

    S. SHARIFZADEH, H. MOJTAHEDI, MAHMOUD JEDI TEHRANI, A. BAYAT, and A. GHADERI, “PRODUCTION AND CHARACTERIZATION OF A MONOCLONAL ANTIBODY AGAINST AN ANTIGEN ON THE SURFACE OF NON-SMALL CELL CARCINOMA OF THE LUNG,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 4, no. 4, pp. 206–214, 2007, [Online]. Available: https://sid.ir/paper/296798/en

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