HIGH SENSITIVITY C-REACTIVE PROTEIN AND IMMUNOGLOBULIN G AGAINST CHLAMYDIA PNEUMONIAE AND CHLAMYDIAL HEAT SHOCK PROTEIN-60 IN ISCHEMIC HEART DISEASE

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JAFARZADEH ABD ELAH; ESMAEILI NADIMI ALI; SHARIATI MAHDI

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Journal: Iranian Journal of Immunology Year:2008 | Volume:5 | Issue:1 Page(s): 51-56

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Title

HIGH SENSITIVITY C-REACTIVE PROTEIN AND IMMUNOGLOBULIN G AGAINST CHLAMYDIA PNEUMONIAE AND CHLAMYDIAL HEAT SHOCK PROTEIN-60 IN ISCHEMIC HEART DISEASE

Author(s)

JAFARZADEH ABD ELAH | ESMAEILI NADIMI ALI | SHARIATI MAHDI | Issue Writer Certificate

Keywords

ISCHEMIC HEART DISEASE

CHLAMYDIA PNEUMONIAE

HSP60

CRP

Abstract

Background: Inflammation and infectious agents such as CHLAMYDIA PNEUMONIAE have been associated with cardiovascular disease.Objective: To evaluate the serum high sensitivity C - reactive protein (hs-CRP) and antibodies against CHLAMYDIA PNEUMONIAE and Chlamydial heat shock protein-60 (Cp-HSP60) in patients with ISCHEMIC HEART DISEASE (IHD).Methods: 62 patients with IHD having either acute myocardial infarction (AMI; n=31) or unstable angina (UA; n=31) and 31 sex- and age- matched healthy subjects as a control group were en-rolled in this study. Serum samples of participants were tested for the presence of hs-CRP and antibodies against C. pneumoniae and Cp-HSP60 using ELISA method.Results: The seroprevalence of anti-C. pneumoniae antibody in AMI group (93.5%) or UA group (90.3%) was significantly higher than the control group (61.3%; p<0.001). The seroprevalence of anti-Cp-HSP60 IgG was 22.6% in healthy subjects with mean end titer of 43.1 ± 6.32. The seropositive rates of anti-Cp-HSP60 were 48.4%, 54.8% and 51.6% in AMI, UA and the overall IHD groups with mean end titers of 94 ± 22.86, 113.8 ± 24.25 and 103.9 ± 16.57, respectively. Both the seroprevalence and the mean titer of anti-Cp-HSP60 in patients groups were significantly higher than those observed in the control group (p<0.04 and p<0.03, respectively). Moreover, the mean serum hs-CRP levels was significantly higher in the IHD group as compared to the control group (21.6mg/ml ± 3.73vs 2.5mg/ml ± 0.52; p<0.00001). The mean serum hs-CRP levels of AMI (30.3mg/ml ± 6.07) or UA (12.9mg/ml ± 3.85) groups were also significantly higher than those observed in the control group (p<0.00001 and p<0.001, respectively). Further-more, the difference of the mean serum hs-CRP levels between AMI and UA groups was also significant (p<0.02).Conclusions: These results showed that the seroprevalence of antibodies against C. pneumoniae and Cp-HSP60 and the serum levels of hs-CRP and anti-Cp-HSP60 IgG were higher in patients with IHD.

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APA: Copy

JAFARZADEH, ABD ELAH, ESMAEILI NADIMI, ALI, & SHARIATI, MAHDI. (2008). HIGH SENSITIVITY C-REACTIVE PROTEIN AND IMMUNOGLOBULIN G AGAINST CHLAMYDIA PNEUMONIAE AND CHLAMYDIAL HEAT SHOCK PROTEIN-60 IN ISCHEMIC HEART DISEASE. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 5(1), 51-56. SID. https://sid.ir/paper/296805/en

Vancouver: Copy

JAFARZADEH ABD ELAH, ESMAEILI NADIMI ALI, SHARIATI MAHDI. HIGH SENSITIVITY C-REACTIVE PROTEIN AND IMMUNOGLOBULIN G AGAINST CHLAMYDIA PNEUMONIAE AND CHLAMYDIAL HEAT SHOCK PROTEIN-60 IN ISCHEMIC HEART DISEASE. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2008;5(1):51-56. Available from: https://sid.ir/paper/296805/en

IEEE: Copy

ABD ELAH JAFARZADEH, ALI ESMAEILI NADIMI, and MAHDI SHARIATI, “HIGH SENSITIVITY C-REACTIVE PROTEIN AND IMMUNOGLOBULIN G AGAINST CHLAMYDIA PNEUMONIAE AND CHLAMYDIAL HEAT SHOCK PROTEIN-60 IN ISCHEMIC HEART DISEASE,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 5, no. 1, pp. 51–56, 2008, [Online]. Available: https://sid.ir/paper/296805/en

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