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Information Journal Paper

Title

ASSOCIATION OF CCR5-59029 A/G AND CCR2-V64I VARIANTS WITH RENAL ALLOGRAFT SURVIVAL

Pages

  201-206

Abstract

 Background: Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies.Objective: The aim of current investigation was to study the impact of polymor-phisms of CCR5D32, CCR5- 59029 A/G and CCR2-V64I on renal allograft survival.Methods: Using PCR and PCR-RFLP methods in 84 renal transplant recipients, the influ-ence of CCR5D32, CCR5- 59029 A/G and CCR2-V64I polymorphisms on renal allograft survival in two rejector and non-rejector groups were examined. Rejector group was de-fined as having rejection before 1 year and non-rejector group had stable graft function at least for 5 years.Results: Significant reductions were found in the risk of renal transplant rejection in recipients possessing the CCR2-64I (A) allele (p=0.03) or 59029-A allele (p=0.03) compared to non-rejector group. There were no significant differences in the fre-quency of CCR5D32 polymorphism in rejector group compared to non-rejector group (p>0.05).Conclusion: It was possible to conclude that the CHEMOKINE RECEPTORS CCR2-V64I (A) and CCR5- 59029 A alleles may influence renal allograft survival.

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    Cite

    APA: Copy

    OMRANI, M.D., MOKHTARI, MOHAMMAD REZA, TAGHIZADEH, ALI, BAGHERI, MORTEZA, & AHMADPOUR, PEDRAM. (2008). ASSOCIATION OF CCR5-59029 A/G AND CCR2-V64I VARIANTS WITH RENAL ALLOGRAFT SURVIVAL. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 5(4), 201-206. SID. https://sid.ir/paper/296826/en

    Vancouver: Copy

    OMRANI M.D., MOKHTARI MOHAMMAD REZA, TAGHIZADEH ALI, BAGHERI MORTEZA, AHMADPOUR PEDRAM. ASSOCIATION OF CCR5-59029 A/G AND CCR2-V64I VARIANTS WITH RENAL ALLOGRAFT SURVIVAL. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2008;5(4):201-206. Available from: https://sid.ir/paper/296826/en

    IEEE: Copy

    M.D. OMRANI, MOHAMMAD REZA MOKHTARI, ALI TAGHIZADEH, MORTEZA BAGHERI, and PEDRAM AHMADPOUR, “ASSOCIATION OF CCR5-59029 A/G AND CCR2-V64I VARIANTS WITH RENAL ALLOGRAFT SURVIVAL,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 5, no. 4, pp. 201–206, 2008, [Online]. Available: https://sid.ir/paper/296826/en

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