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Information Journal Paper

Title

NULL ALLELE FREQUENCIES AT HLA-G LOCUS IN IRANIAN HEALTHY SUBJECTS

Pages

  207-211

Keywords

HLA-G*0105N ANTIGEN 

Abstract

 Background: HLA-G gene contains 15 alleles including a null allele, HLA-G*0105N. Previous studies have shown that HLA-G*0105N does not encode the complete HLA-G1 or HLA-G5 isoforms but encodes a functional HLA-G protein with the ability to in-hibit NK cell cytolysis. Thus, although the biological functions of HLA-G1 and HLA-G5 proteins are abrogated, other isoforms such as HLA-G2 can replace their roles. Stud-ies on the null allele of HLA-G gene could be useful in understanding the genetic vari-ants of HLA-G alleles in ethnic groups.Objective: The goal of this research was to de-termine the FREQUENCY of HLA-G*0105N null allele in IRANian healthy subjects.Methods: The FREQUENCY of HLA-G*0105N null allele was evaluated in IRANian healthy sub-jects by PCR-RFLP method. Genomic DNA was isolated from the whole blood of 100 randomly selected, healthy, unrelated IRANian individuals using salting-out technique followed by PCR amplification of the exon 3 of HLA-G gene. PCR products were di-gested with PpUM-1 and the resulted fragments were analyzed using gel electrophore-sis.Results: In this study the restriction enzyme digestion confirmed homozygous HLA-G*0105N null allele for 9% of the population. Furthermore obtained results indi-cated that the total FREQUENCY of HLA-G*0105N null allele was 20% in the studied population of IRAN.Conclusion: The final data analysis showed that the total FREQUENCY of this allele in IRANian people was higher than other ethnic groups that have been stud-ied so far.

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    Cite

    APA: Copy

    RAHIMI, ROGHAYEH, ZAVARAN HOSSEINI, A., & YARI, FATEMEH. (2008). NULL ALLELE FREQUENCIES AT HLA-G LOCUS IN IRANIAN HEALTHY SUBJECTS. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 5(4), 207-211. SID. https://sid.ir/paper/296827/en

    Vancouver: Copy

    RAHIMI ROGHAYEH, ZAVARAN HOSSEINI A., YARI FATEMEH. NULL ALLELE FREQUENCIES AT HLA-G LOCUS IN IRANIAN HEALTHY SUBJECTS. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2008;5(4):207-211. Available from: https://sid.ir/paper/296827/en

    IEEE: Copy

    ROGHAYEH RAHIMI, A. ZAVARAN HOSSEINI, and FATEMEH YARI, “NULL ALLELE FREQUENCIES AT HLA-G LOCUS IN IRANIAN HEALTHY SUBJECTS,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 5, no. 4, pp. 207–211, 2008, [Online]. Available: https://sid.ir/paper/296827/en

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