GANODERMA LUCIDUM INDUCES THE EXPRESSION OF CD40/CD86 ON PERIPHERAL BLOOD MONOCYTES

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AHMADI KAZEM; RIAZIPOUR M.

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Journal Paper

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Journal: Iranian Journal of Immunology Year:2009 | Volume:6 | Issue:2 Page(s): 87-91

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Information Journal Paper

Title

GANODERMA LUCIDUM INDUCES THE EXPRESSION OF CD40/CD86 ON PERIPHERAL BLOOD MONOCYTES

Author(s)

AHMADI KAZEM | RIAZIPOUR M. | Issue Writer Certificate

Keywords

GANODERMA LUCIDUM

MONOCYTES

CD14

CD40

CD80

Abstract

Background: The major immuno-modulating effects of GANODERMA LUCIDUM include mitogenicity and activation of immune effector cells such as T cells, macrophages and natural killer cells resulting in the production of cytokines.Objective: The purpose of this study was to evaluate the expression of CD40 and CD80 by G. lucidum-treated human peripheral blood mononuclear cells.Methods: MONOCYTES were isolated and incubated at 37oC and 5% CO2 for 24 h and 48 h in the presence or absence of different concentrations of G. lucidum. Cells were then incubated with labelled monoclonal antibodies against CD14, CD40 and B7-1(CD80) molecules utilizing standard protocols, and analyzed by flow cytometry.Results: The results showed that incubation of MONOCYTES with G. lucidum led to marked enhancement of CD40 and B7-1 expression in a doseand time- dependent manner (p<0.001). G. lucidum was more effective in enhancing the expression of CD80 and CD40 molecules of cells obtained from females than male donors (p<0.001).Conclusion: G. lucidum enhanced the expression of CD40 and CD80 molecules on peripheral blood monocytic cells derived from both sexes in a dosedependent manner, with a preferential higher effect on cells obtained from female donors.

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APA: Copy

AHMADI, KAZEM, & RIAZIPOUR, M.. (2009). GANODERMA LUCIDUM INDUCES THE EXPRESSION OF CD40/CD86 ON PERIPHERAL BLOOD MONOCYTES. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 6(2), 87-91. SID. https://sid.ir/paper/296843/en

Vancouver: Copy

AHMADI KAZEM, RIAZIPOUR M.. GANODERMA LUCIDUM INDUCES THE EXPRESSION OF CD40/CD86 ON PERIPHERAL BLOOD MONOCYTES. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2009;6(2):87-91. Available from: https://sid.ir/paper/296843/en

IEEE: Copy

KAZEM AHMADI, and M. RIAZIPOUR, “GANODERMA LUCIDUM INDUCES THE EXPRESSION OF CD40/CD86 ON PERIPHERAL BLOOD MONOCYTES,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 6, no. 2, pp. 87–91, 2009, [Online]. Available: https://sid.ir/paper/296843/en

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