CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes

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Fakhari Shohreh; BASHIRI HAMED; GHADERI BAYAZID; Tari Kaveh; JALILI ALI

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Journal Paper

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Journal: Iranian Journal of Immunology Year:2019 | Volume:16 | Issue:2 Page(s): 142-150

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Title

CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes

Author(s)

Keywords

C1q

CD93

Multiple Myeloma

Abstract

Background: CD93 has originally been known as a C1q receptor, and many studies have demonstrated that CD93 is expressed on hematopoietic stem cells, B cell progenitors, myeloid and monocytic cells. Moreover, CD93 is shown to be expressed on long-lived plasma cells, and CD93 deficient-mice display an impairment in plasma cell development. Objective: To investigate the expression of CD93 on Multiple Myeloma (MM) cells. Methods: Human MM and B cell lines were cultured, and the expression of CD93 was examined on these cells by quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) and Fluorescence Activated Cell Sorting (FACS). In addition, CD19+ primary B cells and CD19-/CD138+ primary MM cells were isolated by MACS columns, and CD93 expression was further analyzed on these cells. Results: qRT-PCR data showed that CD93 expression at mRNA level was much higher in MM cell lines compared with B cell lines. In addition, MM cell lines expressed a higher amount of surface CD93 at protein level compared with B cell lines. More importantly, CD93 expression was significantly higher in CD19-/CD138+ primary MM cells than in CD19+ primary B cells isolated from the bone marrow of patients with MM. Conclusion: We demonstrated that CD93 is expressed on myeloma cells and, that CD93 could play a key role in the pathogenesis of MM. Further studies are necessary to explore this possible role.

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APA: Copy

Fakhari, Shohreh, BASHIRI, HAMED, GHADERI, BAYAZID, Tari, Kaveh, & JALILI, ALI. (2019). CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 16(2), 142-150. SID. https://sid.ir/paper/296916/en

Vancouver: Copy

Fakhari Shohreh, BASHIRI HAMED, GHADERI BAYAZID, Tari Kaveh, JALILI ALI. CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2019;16(2):142-150. Available from: https://sid.ir/paper/296916/en

IEEE: Copy

Shohreh Fakhari, HAMED BASHIRI, BAYAZID GHADERI, Kaveh Tari, and ALI JALILI, “CD93 is Selectively Expressed on Human Myeloma Cells but Not on B Lymphocytes,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 16, no. 2, pp. 142–150, 2019, [Online]. Available: https://sid.ir/paper/296916/en

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