Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer

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Arabpour Mohsen; Ghods Atri; SHARIAT MAHMOUD; TALEEI ABD ALRASOUL; MEHDIPOUR FERESHTEH; GHADERI ABBAS

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Journal: Iranian Journal of Immunology Year:2019 | Volume:16 | Issue:2 Page(s): 108-116

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Title

Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer

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Keywords

4-1BBL

Breast Cancer

B Cells

Tumor Draining Lymph Nodes

Abstract

Background: B Cells can increase the expression of granzyme B in CD8+ T cells through 4-1BBL/4-1BB interaction and promote anti-tumor immunity. Objective: To investigate the expression of 4-1BBL on B Cells in the breast Tumor Draining Lymph Nodes (TDLNs) and its association with disease parameters. Methods: Using Ficoll-Hypaque gradient centrifugation, mononuclear cells were isolated from axillary lymph nodes of 42 patients. Cells received 4 hours of PMA/Ionomycin stimulation, in vitro. Both unstimulated and stimulated cells were stained with anti‒ CD19 and anti‒ 4-1BBL antibodies and subjected to flow cytometry. Results: 4-1BBL expression was detected on 2. 8 ± 1. 7% of unstimulated B Cells, while 27. 4 ± 11. 9% of B Cells expressed this co-stimulatory molecule following stimulation. In steady state, the percentage of 4-1BBL+ B Cells was not associated with cancer characteristics. However, in patients with invasive ductal carcinoma, the percentage of 4-1BBL expressing B Cells in stimulated condition had a decreasing trend in grade III, compared to grade II+I. In addition, significantly higher frequency of 4-1BBL+ B Cells was seen in the TDLNs of ER+ or PR+ compared with ER‒ or PR‒ patients (p=0. 021 and p=0. 015, respectively). No significant associations were observed between the frequency of 4-1BBL+ B Cells and the number of involved LNs, Her2 expression or disease stage. Conclusions: The frequency of 4-1BBL+ B Cells significantly increased following a short time activation, and showed relative and significant associations with tumor grade and estrogen receptor status, respectively. More investigations are required to evaluate the potential of 4-1BBL+ B Cells for use in immunotherapy.

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APA: Copy

Arabpour, Mohsen, Ghods, Atri, SHARIAT, MAHMOUD, TALEEI, ABD ALRASOUL, MEHDIPOUR, FERESHTEH, & GHADERI, ABBAS. (2019). Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 16(2), 108-116. SID. https://sid.ir/paper/296918/en

Vancouver: Copy

Arabpour Mohsen, Ghods Atri, SHARIAT MAHMOUD, TALEEI ABD ALRASOUL, MEHDIPOUR FERESHTEH, GHADERI ABBAS. Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2019;16(2):108-116. Available from: https://sid.ir/paper/296918/en

IEEE: Copy

Mohsen Arabpour, Atri Ghods, MAHMOUD SHARIAT, ABD ALRASOUL TALEEI, FERESHTEH MEHDIPOUR, and ABBAS GHADERI, “Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 16, no. 2, pp. 108–116, 2019, [Online]. Available: https://sid.ir/paper/296918/en

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