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Information Journal Paper

Title

NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer

Pages

  291-298

Abstract

 Background: NK (natural killer) and NKT (natural killer T) cells, as components of innate immune system, play a crucial role in tumor progression and dissemination. Objective: To investigate the percentages of NK Cells, NKT Cells, iNKT (invariant natural killer T) cells, total T lymphocytes as well as activated T lymphocytes, in tumor draining Lymph Nodes (TDLNs) of patients with Breast Cancer (BC) and their association with different clinic-pathological features of the patients. Methods: Axillary Lymph Nodes were obtained from 30 Iranian women with Breast Cancer. After routine pathological evaluations, mononuclear cells were separated from their Lymph Nodes and incubated with appropriate fluorochrome conjugated monoclonal antibodies specific for CD3, HLA-DR, CD16/56, and Vα 24Jα 18-TCR. Data were collected on a four-color flow cytometer and analyzed by CellQuest software. Results: The mean percentages of NK (CD3-CD16/56+), NKT (CD3+CD16/56+) and iNKT (Vα 24Jα 18-TCR+) cells in TDLNs mononuclear cells of BC patients were 2. 04%, 2. 44% and 0. 1%, respectively. A significant decrease in the percentages of NK and iNKT subsets in patients with grade I was observed compared to grade III (p=0. 03 and p=0. 01, respectively). Moreover, NK Cells were increased in patients with grade III of BC compared to grade II (p= 0. 003). Conclusion: The increase in the percentage of NK and iNKT Cells in TDLNs of patients with higher grade of BC might suggest a suppressive phenotype for these cells in Breast Cancer, which merit more functional investigation.

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    APA: Copy

    REZAEIFARD, SOMAYEH, SAFAEI, AKBAR, TALEI, ABDOLRASOUL, Faghih, Zahra, & ERFANI, NASROLLAH. (2019). NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 16(4), 291-298. SID. https://sid.ir/paper/296975/en

    Vancouver: Copy

    REZAEIFARD SOMAYEH, SAFAEI AKBAR, TALEI ABDOLRASOUL, Faghih Zahra, ERFANI NASROLLAH. NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2019;16(4):291-298. Available from: https://sid.ir/paper/296975/en

    IEEE: Copy

    SOMAYEH REZAEIFARD, AKBAR SAFAEI, ABDOLRASOUL TALEI, Zahra Faghih, and NASROLLAH ERFANI, “NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 16, no. 4, pp. 291–298, 2019, [Online]. Available: https://sid.ir/paper/296975/en

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