مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SHORT PAPER: Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Pages

  327-333

Abstract

 Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1 , IL-6, and TNF- ) in patients with Non-Alcoholic Fatty Liver (NAFL) and Non-Alcoholic Steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy volunteers. The plasma level of IL-1 , IL-6, and TNF- were determined by ELISA, and biochemical parameters were measured using colorimetric methods. Results: IL-1 and IL-6 levels were significantly higher in patients with NASH compared with NAFL and control group. However, TNF- levels had no significant variations in NAFL and NASH patients compared to the control group (p=0. 903 and p=0. 960, respectively). Conclusion: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH.

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    Cite

    APA: Copy

    HADINIA, ABOLGHASEM, Doustimotlagh, Amir Hossein, Goodarzi, Hamed Reza, ARYA, ARASH, & JAFARINIA, MOJTABA. (2019). SHORT PAPER: Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 16(4), 327-333. SID. https://sid.ir/paper/296976/en

    Vancouver: Copy

    HADINIA ABOLGHASEM, Doustimotlagh Amir Hossein, Goodarzi Hamed Reza, ARYA ARASH, JAFARINIA MOJTABA. SHORT PAPER: Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2019;16(4):327-333. Available from: https://sid.ir/paper/296976/en

    IEEE: Copy

    ABOLGHASEM HADINIA, Amir Hossein Doustimotlagh, Hamed Reza Goodarzi, ARASH ARYA, and MOJTABA JAFARINIA, “SHORT PAPER: Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 16, no. 4, pp. 327–333, 2019, [Online]. Available: https://sid.ir/paper/296976/en

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