Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study

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HOSSEINZADEH MORTEZA; NAFAR MOHSEN; AHMADPOOR PEDRAM; Noorbakhsh Farshid; YEKANINEJAD MIR SAEED; NIKNAM MOHAMMAD HOSSEIN; AMIRZARGAR ALIAKBAR

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Journal: IRANIAN JOURNAL OF IMMUNOLOGY Year:2017 | Volume:14 | Issue:1 Page(s): 24-34

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Title

Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study

Author(s)

Keywords

Allograft Function

Kidney Transplant

Toll-Like Receptors

Abstract

Background: The incidence of ischemic reperfusion injury (IRI) in early phase posttransplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. Objective: To investigate whether the expression of TLRs in peripheral blood mononuclear cells (PBMCs) can predict the clinical outcome of kidney allografts. Methods: We obtained blood samples from 52 renal transplant patients before transplant, and 2, 90, and 180 days post-transplantation in order to analyze the surface expressions of TLR-2 and TLR-4 on peripheral blood monocytes. The expression patterns of TLR-2 and TLR-4 were compared between patients with graft dysfunction (GD) and those with well-functioning graft (WFG). Results: Significantly different mean dynamic changes in surface expression of TLR-2, according to percentage of TLR-2+ cells, between (the GD and WFG) groups existed at most time-points before and after renal transplantation (p=0. 007) with the exception of day 2 post-transplantation. We observed significantly higher mean fluorescence intensities of TLR-2 and TLR-4 on CD14+ cells in the GD group compared to the WFG group. This finding was particularly observed 180 days post-transplantation (p=0. 001). Based on TLR-2 and TLR-4 protein expression for each step, multiple logistic regression and ROC curve analysis revealed that an increase in CD14+ TLR-2+ monocytes within the 90 days post-transplantaton was associated with increased risk of GD at 180 and 365 days post-transplantation [odds ratio (OR)=1. 27, p=0. 005)]. Conclusion: Sequential monitoring of TLR-2 and TLR-4 expression patterns in peripheral blood monocytes appear to be prognostic and predictive biomarkers for early and late kidney allograft outcomes.

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APA: Copy

HOSSEINZADEH, MORTEZA, NAFAR, MOHSEN, AHMADPOOR, PEDRAM, Noorbakhsh, Farshid, YEKANINEJAD, MIR SAEED, NIKNAM, MOHAMMAD HOSSEIN, & AMIRZARGAR, ALIAKBAR. (2017). Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 14(1), 24-34. SID. https://sid.ir/paper/297011/en

Vancouver: Copy

HOSSEINZADEH MORTEZA, NAFAR MOHSEN, AHMADPOOR PEDRAM, Noorbakhsh Farshid, YEKANINEJAD MIR SAEED, NIKNAM MOHAMMAD HOSSEIN, AMIRZARGAR ALIAKBAR. Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2017;14(1):24-34. Available from: https://sid.ir/paper/297011/en

IEEE: Copy

MORTEZA HOSSEINZADEH, MOHSEN NAFAR, PEDRAM AHMADPOOR, Farshid Noorbakhsh, MIR SAEED YEKANINEJAD, MOHAMMAD HOSSEIN NIKNAM, and ALIAKBAR AMIRZARGAR, “Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 14, no. 1, pp. 24–34, 2017, [Online]. Available: https://sid.ir/paper/297011/en

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