DIAZOXIDE, A KATP CHANNEL OPENER, PREVENTED ETHANOL-INDUCED GASTRIC ULCERATION IN RATS

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RAHGOZAR MAHDI; BAKHTIARIAN A.; DJAHANGUIRI B.; PAZOUKI TOROUDI H.R.

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Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2002 | Volume:1 | Issue:1 Page(s): 5-7

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Title

DIAZOXIDE, A KATP CHANNEL OPENER, PREVENTED ETHANOL-INDUCED GASTRIC ULCERATION IN RATS

Author(s)

RAHGOZAR MAHDI | BAKHTIARIAN A. | DJAHANGUIRI B. | PAZOUKI TOROUDI H.R. | Issue Writer Certificate

Keywords

ETHANOL

POTASSIUM CHANNEL MODULATORS

RATS

STOMACH ULCERATION

Abstract

ETHANOL-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in RATS. Gastric lesions were quantified. Fasting blood glucose (FBS) levels were measured enzymatically. EIGU was prevented by diazoxide and aggravated by glibenclamide. Diazoxide increased and glibenclamide decreased FBS respectively. The present study shows that KATP modulators are involved in the production of EIGU with a mechanism which remains to be elucidated.

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APA: Copy

RAHGOZAR, MAHDI, BAKHTIARIAN, A., DJAHANGUIRI, B., & PAZOUKI TOROUDI, H.R.. (2002). DIAZOXIDE, A KATP CHANNEL OPENER, PREVENTED ETHANOL-INDUCED GASTRIC ULCERATION IN RATS . IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 1(1), 5-7. SID. https://sid.ir/paper/297032/en

Vancouver: Copy

RAHGOZAR MAHDI, BAKHTIARIAN A., DJAHANGUIRI B., PAZOUKI TOROUDI H.R.. DIAZOXIDE, A KATP CHANNEL OPENER, PREVENTED ETHANOL-INDUCED GASTRIC ULCERATION IN RATS . IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2002;1(1):5-7. Available from: https://sid.ir/paper/297032/en

IEEE: Copy

MAHDI RAHGOZAR, A. BAKHTIARIAN, B. DJAHANGUIRI, and H.R. PAZOUKI TOROUDI, “DIAZOXIDE, A KATP CHANNEL OPENER, PREVENTED ETHANOL-INDUCED GASTRIC ULCERATION IN RATS ,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 1, no. 1, pp. 5–7, 2002, [Online]. Available: https://sid.ir/paper/297032/en

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