ANTISTEROIDOGENIC ACTIVITY OF ETHANOL EXTRACT OF AMMANIA BACCIFERA (L.) WHOLE PLANT IN FEMALE ALBINOMICE OVARIES

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DHANAPAL R.; KAVIMANI S.; VRUSHABENDRA SWAMY B.M.; GUPTA M.; BASU SK.

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Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2005 | Volume:4 | Issue:1 Page(s): 43-46

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Title

ANTISTEROIDOGENIC ACTIVITY OF ETHANOL EXTRACT OF AMMANIA BACCIFERA (L.) WHOLE PLANT IN FEMALE ALBINOMICE OVARIES

Author(s)

Keywords

AMMANIA BACCIFERA

OVARIAN STEROIDOGENESIS

DELTA 5-3#-HSD

G-6-PD

MEDICINAL PLANT

Abstract

Ethanol (90%) extract of AMMANIA BACCIFERA (L.) whole plant (EEAB) was evaluated for possible antisteroidogenic activity in mature female mice ovaries. The ethanol extract at the doses of 10.0,200 and 400 mg /kg body weight (Lp) arrested the normal estrus cycle at dioestrus phase and significantly decreased weight of ovaries. The cholesterol and ascorbic acid content in ovaries were significantly elevated in treated mice. The extract also significantly inhibited the activity of D5-3font face="Symbol">bb-HSD)and Glucose-6-phosphate dehydrogenase (G-6-PD), the two key enzymes involved in ovarian steroidogenesis. Results of this study suggested that the ethanol extract of whole plant of Ammania baccifera (L.) acts as an antisteroidogenic agent.

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APA: Copy

DHANAPAL, R., KAVIMANI, S., VRUSHABENDRA SWAMY, B.M., GUPTA, M., & BASU, SK.. (2005). ANTISTEROIDOGENIC ACTIVITY OF ETHANOL EXTRACT OF AMMANIA BACCIFERA (L.) WHOLE PLANT IN FEMALE ALBINOMICE OVARIES. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 4(1), 43-46. SID. https://sid.ir/paper/297069/en

Vancouver: Copy

DHANAPAL R., KAVIMANI S., VRUSHABENDRA SWAMY B.M., GUPTA M., BASU SK.. ANTISTEROIDOGENIC ACTIVITY OF ETHANOL EXTRACT OF AMMANIA BACCIFERA (L.) WHOLE PLANT IN FEMALE ALBINOMICE OVARIES. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2005;4(1):43-46. Available from: https://sid.ir/paper/297069/en

IEEE: Copy

R. DHANAPAL, S. KAVIMANI, B.M. VRUSHABENDRA SWAMY, M. GUPTA, and SK. BASU, “ANTISTEROIDOGENIC ACTIVITY OF ETHANOL EXTRACT OF AMMANIA BACCIFERA (L.) WHOLE PLANT IN FEMALE ALBINOMICE OVARIES,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 4, no. 1, pp. 43–46, 2005, [Online]. Available: https://sid.ir/paper/297069/en

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