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Information Journal Paper

Title

STUDIES ON ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC PROPERTIES OF METHANOL EXTRACT OF CAESALPINIA BONDUCELLA LEAVES IN EXPERIMENTAL ANIMAL MODELS

Pages

  30-34

Abstract

 The methanol extract of CAESALPINIA BONDUCELLA leaves were investigated for ANTI-INFLAMMATORY, ANALGESIC and ANTIPYRETIC activity at the doses of 50, 100 and 200 mg/kg, body weight. The experimental paradigms used were carrageenan, dextran, histamine induced pedal edema and cotton pellet induced granuloma for ANTI-INFLAMMATORY activity, while hot plate and acetic acid induced writhing methods were used to assess ANALGESIC activity. Yeast-induced hyperpyrexia was used to evaluate the ANTIPYRETIC activity. In acute phase inflammation, a maximum inhibition 50.6% (P < 0.05),51.1% (P < 0.05) and 52.3% (P < 0.05) was noted at the dose of 200 mg/kg after 3 h of treatment with methanol extract of CAESALPINIA BONDUCELLA (MECB) in carrageenan, dextran and histamine induced pedal edema respectively. In the chronic model (cotton pellet induced granuloma) the MECB (200 mg/kg) and standard drug (Indomethacin 10 mg/kg) showed decreased formation of granuloma tissue by 51.8% (P < 0.05) and 56.6% (P < 0.05) respectively. The extract also produced significant (P < 0.01) ANALGESIC activity in both paradigms. In addition, MECB potentiated the morphine and aspirin induced analgesia. A significant (P < 0.01) reduction in hyperpyrexia in rat was also produced by the extract. This study exhibits that the methanol extracts of leaves of C. bonducella possess ANTI-INFLAMMATORY, ANALGESIC and ANTIPYRETIC activities.

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    • Cite

    APA: Copy

    GUPTA, M., MAZUMDER, U.K., SAMBATH KUMAR, R., & SIVA KUMAR, T.. (2003). STUDIES ON ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC PROPERTIES OF METHANOL EXTRACT OF CAESALPINIA BONDUCELLA LEAVES IN EXPERIMENTAL ANIMAL MODELS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 2(2), 30-34. SID. https://sid.ir/paper/297077/en

    Vancouver: Copy

    GUPTA M., MAZUMDER U.K., SAMBATH KUMAR R., SIVA KUMAR T.. STUDIES ON ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC PROPERTIES OF METHANOL EXTRACT OF CAESALPINIA BONDUCELLA LEAVES IN EXPERIMENTAL ANIMAL MODELS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2003;2(2):30-34. Available from: https://sid.ir/paper/297077/en

    IEEE: Copy

    M. GUPTA, U.K. MAZUMDER, R. SAMBATH KUMAR, and T. SIVA KUMAR, “STUDIES ON ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC PROPERTIES OF METHANOL EXTRACT OF CAESALPINIA BONDUCELLA LEAVES IN EXPERIMENTAL ANIMAL MODELS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 2, no. 2, pp. 30–34, 2003, [Online]. Available: https://sid.ir/paper/297077/en

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