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Cites:

1

Information Journal Paper

Title

PROTECTIVE EFFECT OF N-ACETYL CYSTEINE IN CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS

Pages

  118-123

Abstract

 The present study determines the efficacy of N-ACETYL CYSTEINE (NAC) on marker enzymes, lipid peroxida-protection and antioxidants in CARBON TETRACHLORIDE induced HEPATOTOXICITY in rats. CARBON TETRACHLORIDE (CCl4) (3 mL /kg/week) administered subcutaneously to albino Wistar rats  for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transaminase, γ-glutamyl transferase and alkaline phosphatase and increased the levels of thiobarbituric acid reactive substances and hydroperoxides in plasma and tissues (liver and kidney). A significant decrease in the levels of plasma antioxidants (glutathione, vitamin C and vitamin E) was also noted. Further, a decrease in the concentration of glutathione and the activities of superoxide dismutase, catalase and glutathione peroxidase in the tissues were observed. N-ACETYL CYSTEINE (150 mg/kg) was orally administered to normal and CARBON TETRACHLORIDE-treated rats for a period of three months. N-ACETYL CYSTEINE decreased the activities of marker enzymes, lipid peroxidation and improved the antioxidant status in CARBON TETRACHLORIDE-treated rats. But There were no significant alterations in these parameters in normal rats treated with N-ACETYL CYSTEINE. Histopathological observations of the liver also showed the protective effect of N-ACETYL CYSTEINE in CARBON TETRACHLORIDE-induced HEPATOTOXICITY in rats. The results of this study show the protective action of N-ACETYL CYSTEINE in CARBON TETRACHLORIDE-induced HEPATOTOXICITY in rats. This is mainly due to the effective antioxdant potential of N-ACETYL CYSTEINE. 

Cites

References

Cite

APA: Copy

KAMALAKKANNAN, N., RUKKUMANI, R., ARUNA, K., VARMA, P.S., VISWANATHAN, P., & MENON, V.P.. (2005). PROTECTIVE EFFECT OF N-ACETYL CYSTEINE IN CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 4(2), 118-123. SID. https://sid.ir/paper/297094/en

Vancouver: Copy

KAMALAKKANNAN N., RUKKUMANI R., ARUNA K., VARMA P.S., VISWANATHAN P., MENON V.P.. PROTECTIVE EFFECT OF N-ACETYL CYSTEINE IN CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2005;4(2):118-123. Available from: https://sid.ir/paper/297094/en

IEEE: Copy

N. KAMALAKKANNAN, R. RUKKUMANI, K. ARUNA, P.S. VARMA, P. VISWANATHAN, and V.P. MENON, “PROTECTIVE EFFECT OF N-ACETYL CYSTEINE IN CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 4, no. 2, pp. 118–123, 2005, [Online]. Available: https://sid.ir/paper/297094/en

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