ROLE OF CYTOKINES IN PATHOPHYSIOLOGY OF ASTHMA

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MAHAJAN SH.; MEHTA A.A.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2006 | Volume:5 | Issue:1 Page(s): 1-14

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Information Journal Paper

Title

ROLE OF CYTOKINES IN PATHOPHYSIOLOGY OF ASTHMA

Author(s)

MAHAJAN SH. | MEHTA A.A. | Issue Writer Certificate

Keywords

ASTHMA

HYPERREACTIVITY

BRONCHOCONSTRICTION

CYTOKINES

Abstract

The worldwide incidence, morbidity and mortality of ASTHMA are increasing dramatically. It is one of the most common disorders encountered in clinical medicine in both children and adults. It affects approxi mately 5% of the adult population in the western world and its reported incidence is increasing vigorously in many developed nations. A network of novel mediators known as ‘pleiotropic CYTOKINES’ regulate the intermittent airway inflammation, bronchial smooth muscle HYPERREACTIVITY and bronchoconstricion under lying ASTHMA. Preclinical and clinical data suggest that, the pathophysiological features of ASTHMA are thought to result from the aberrant expansion of CYTOKINES and chemokines. CYTOKINES are small extracel lular signaling protein produced by different cells and possess a wide spectrum of biological activities due to their redundancy and pleiotropic properties. They are critical to the functioning of both innate and adap tive immune responses. CYTOKINES and their receptors exhibit very high affinity for each other. Because of this high affinity, picomolar concentrations of CYTOKINES can mediate a biological effect. The major groups of CYTOKINES are lymphokines, proinflammatory cytokine, inhibitory CYTOKINES and growth factors. Patho physiology of ASTHMA is still poorly understood and its cause remains unknown. On this basis, this review will concentrate on the synthesis, release and functional role of each cytokine in the pathophysiology of ASTHMA.

Cites

ROLE OF THE IMMUNE CELLS, MEDIATORS AND CYTOKINES IN PATHOGENESIS OF ASTHMA: A REVIEW ARTICLE

References

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APA: Copy

MAHAJAN, SH., & MEHTA, A.A.. (2006). ROLE OF CYTOKINES IN PATHOPHYSIOLOGY OF ASTHMA. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 5(1), 1-14. SID. https://sid.ir/paper/297106/en

Vancouver: Copy

MAHAJAN SH., MEHTA A.A.. ROLE OF CYTOKINES IN PATHOPHYSIOLOGY OF ASTHMA. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2006;5(1):1-14. Available from: https://sid.ir/paper/297106/en

IEEE: Copy

SH. MAHAJAN, and A.A. MEHTA, “ROLE OF CYTOKINES IN PATHOPHYSIOLOGY OF ASTHMA,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 5, no. 1, pp. 1–14, 2006, [Online]. Available: https://sid.ir/paper/297106/en

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