EFFECT OF SODIUM VALPROATE ON OUABAIN-INDUCED ARRHYTHMIA IN ISOLATED GUINEA-PIG ATRIA

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POUSTI A.; ZARE JAHROMI A.; MALIHI G.; OJAGH ZADEH H.; BOROUMAND K.; DIMYAD T.

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Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2007 | Volume:6 | Issue:1 Page(s): 41-43

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Title

EFFECT OF SODIUM VALPROATE ON OUABAIN-INDUCED ARRHYTHMIA IN ISOLATED GUINEA-PIG ATRIA

Author(s)

Keywords

SODIUM VALPROATE

OUABAIN

ISOLATED ATRIA

Abstract

SODIUM VALPROATE (SV), an antiepileptic drug has several mechanism of action. It inhibits voltage-sensitive Na+ channels and reduces intracellular Na+ accumulation. These actions are similar to that of both phenytoin and carbamazepine. We have investigated the direct cardiac action of SV and its effects on OUABAINinduced arrhythmia in isolated guinea-pig atria. The guinea-pig atrium was dissected out and suspended in modified Krebs solution under physiologic conditions. Drug was added into the solution. The changes in rate and contractions were measured using a physiograph. SV (100-300 mg/ml) caused a dosedependent decrease in contractile force of isolated guineapig atria (9-120%, p<0.001), but no change on the rate of contractions. OUABAIN alone (1.2 mg/ml) produced arrhythmia at 10 min and asystole at 21 min. Pretreatment with SV (200 mg/ml) significantly increased time of onset of arrhythmia to 29 min and asystole to more than 38 min. SV may have a direct cardiac effect to reduce the membrane conductance through ion channels which may decrease OUABAIN toxicity in isolated guinea-pig atria.

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APA: Copy

POUSTI, A., ZARE JAHROMI, A., MALIHI, G., OJAGH ZADEH, H., BOROUMAND, K., & DIMYAD, T.. (2007). EFFECT OF SODIUM VALPROATE ON OUABAIN-INDUCED ARRHYTHMIA IN ISOLATED GUINEA-PIG ATRIA . IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 6(1), 41-43. SID. https://sid.ir/paper/297130/en

Vancouver: Copy

POUSTI A., ZARE JAHROMI A., MALIHI G., OJAGH ZADEH H., BOROUMAND K., DIMYAD T.. EFFECT OF SODIUM VALPROATE ON OUABAIN-INDUCED ARRHYTHMIA IN ISOLATED GUINEA-PIG ATRIA . IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2007;6(1):41-43. Available from: https://sid.ir/paper/297130/en

IEEE: Copy

A. POUSTI, A. ZARE JAHROMI, G. MALIHI, H. OJAGH ZADEH, K. BOROUMAND, and T. DIMYAD, “EFFECT OF SODIUM VALPROATE ON OUABAIN-INDUCED ARRHYTHMIA IN ISOLATED GUINEA-PIG ATRIA ,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 6, no. 1, pp. 41–43, 2007, [Online]. Available: https://sid.ir/paper/297130/en

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