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Information Journal Paper

Title

MEFENAMIC ACID ATTENUATES INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN THE RAT: A BEHAVIORAL ANALYSIS

Pages

  45-49

Abstract

 Intracerebroventricular (ICV) injection of STREPTOZOTOCIN (STZ) in rats is followed by long-term and pro-gressive deficits in LEARNING, MEMORY, and cognitive performance in rats which is somewhat similar to sporadic Alzheimer’s disease (SAD). Epidemiological studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) could delay or slow the clinical expression of SAD. Therefore, the beneficial effect of me-fenamic acid (MA) was investigated on ICV STZ-induced LEARNING, MEMORY, and cognitive impairment in male rats. For this purpose, rats were injected bilaterally with ICV STZ, on days 1 and 3 (3 mg/kg). The STZ-injected rats received MA (30 mg/kg/day, i.p.) starting from day 5 post-surgery for two weeks. The LEARNING and MEMORY performance was assessed using passive avoidance paradigm, and for spatial cog-nition evaluation, radial eight-arm maze (RAM) task was used. It was found out that MA-treated STZ-injected rats showed higher correct choices and lower errors in RAM than vehicle-treated STZ-injected rats. In addition, MA administration significantly attenuated compared to and MEMORY impairment in STZ-injected group in passive avoidance test. These results demonstrate MA efficacy against cognitive deficits as well as LEARNING and MEMORY impairment caused by ICV injection of STZ in rats and its potential in the treatment of some neurodegenerative disorders including SAD.

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    Cite

    APA: Copy

    BALUCHNEJADMOJARAD, TOURANDOKHT, ROGHANI, MEHRDAD, & HOSSEIN ZADEH, SOHEYLA. (2007). MEFENAMIC ACID ATTENUATES INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN THE RAT: A BEHAVIORAL ANALYSIS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 6(1), 45-49. SID. https://sid.ir/paper/297136/en

    Vancouver: Copy

    BALUCHNEJADMOJARAD TOURANDOKHT, ROGHANI MEHRDAD, HOSSEIN ZADEH SOHEYLA. MEFENAMIC ACID ATTENUATES INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN THE RAT: A BEHAVIORAL ANALYSIS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2007;6(1):45-49. Available from: https://sid.ir/paper/297136/en

    IEEE: Copy

    TOURANDOKHT BALUCHNEJADMOJARAD, MEHRDAD ROGHANI, and SOHEYLA HOSSEIN ZADEH, “MEFENAMIC ACID ATTENUATES INTRACEREBROVENTRICULAR STREPTOZOTOCIN-INDUCED COGNITIVE DEFICITS IN THE RAT: A BEHAVIORAL ANALYSIS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 6, no. 1, pp. 45–49, 2007, [Online]. Available: https://sid.ir/paper/297136/en

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