مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

HEPATOPROTECTIVE EFFICACY OF PROPOLIS EXTRACT: A BIOCHEMICAL AND HISTOPATHOLOGICAL APPROACH

Pages

  145-154

Abstract

 Hepatoprotective efficacy of PROPOLIS extract (honeybee hive product, 200 mg/kg, p.o.) was studied against biochemical and histopathological changes induced by carbontetrachloride (CCl4, 0.15 ml/kg, i.p.). Silymarin, a known hepatoprotective drug was used as positive control. Subchronic exposure to CCl4 for 3 weeks (5 days a week) caused sharp elevation in the activity of liver marker enzymes i.e., serum transaminases, alkaline phosphatase and lactate dehydrogenase. CCl4 administration significantly decreased blood glucose level and increased serum proteins. Tissue biochemistry revealed significant reduction in total protein and glycogen contents, activity of alkaline phosphatase and adenosine triphosphatase; and significant increase in acid phosphatase activity in liver and kidney. CCl4-induced oxidative stress was measured by estimating reduced glutathione level and amount of thiobarbituric acid reactive substances  (TBARS) formed as an index of LIPID PEROXIDATION. Hepatorenal glutathione level showed marked depletion, whereas LIPID PEROXIDATION was enhanced significantly. A 5-day treatment of PROPOLIS extract after toxicant administration reversed alterations in blood and tissue biochemical variables including LIVER FUNCTION TEST and markers of oxidative stress almost as same as in silymarin-treated positive control. Histopathological studies of liver and kidney showed improved cellular architecture after PROPOLIS therapy and confirmed its HEPATOPROTECTIVE EFFICACY as a natural miracle.

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    APA: Copy

    BHADAURIA, M., NIRALA, S.K., & SHUKLA, S.. (2007). HEPATOPROTECTIVE EFFICACY OF PROPOLIS EXTRACT: A BIOCHEMICAL AND HISTOPATHOLOGICAL APPROACH. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 6(2), 145-154. SID. https://sid.ir/paper/297160/en

    Vancouver: Copy

    BHADAURIA M., NIRALA S.K., SHUKLA S.. HEPATOPROTECTIVE EFFICACY OF PROPOLIS EXTRACT: A BIOCHEMICAL AND HISTOPATHOLOGICAL APPROACH. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2007;6(2):145-154. Available from: https://sid.ir/paper/297160/en

    IEEE: Copy

    M. BHADAURIA, S.K. NIRALA, and S. SHUKLA, “HEPATOPROTECTIVE EFFICACY OF PROPOLIS EXTRACT: A BIOCHEMICAL AND HISTOPATHOLOGICAL APPROACH,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 6, no. 2, pp. 145–154, 2007, [Online]. Available: https://sid.ir/paper/297160/en

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