THE EFFECT OF BUBBLE SURFACE CHARGE ON PHONOPHORESIS: IMPLICATION IN TRANSDERMAL PIROXICAM DELIVERY

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SHIRAN M.B.; MOTEVALIAN M.; RAVANFAR R.; BOHLOULI SH.

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Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2008 | Volume:7 | Issue:1 Page(s): 15-19

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Title

THE EFFECT OF BUBBLE SURFACE CHARGE ON PHONOPHORESIS: IMPLICATION IN TRANSDERMAL PIROXICAM DELIVERY

Author(s)

SHIRAN M.B. | MOTEVALIAN M. | RAVANFAR R. | BOHLOULI SH. | Issue Writer Certificate

Keywords

PIROXICAM

PHONOPHORESIS

CAVITATION

MICRO-STREAMING

Abstract

It is over several decades that ultrasound is used to enhance the transdermal drug delivery (phonphore sis). The mechanism of the enhancement is not fully understood and the ability of ultrasound on the en hancement for some drugs is unclear. The effect of continuous wave 870 KHz ultrasound at intensity of 1 W/cm2 for 15 minutes on transdermal absorption of PIROXICAM from solution and gel formulations in hair less rat skin was studied. Exposure to ultrasound increased the rate of diffusion from gel and solution of PIROXICAM to 10 and 3 times higher than that in skins not exposed to ultrasound. We strongly believe that the lower diffusion of PIROXICAM from the solution is caused by extra-bubbles generated by ultrasound. It can be suggested that CAVITATION activity and its negative surface charges play a dominant rule in phono phoresis.

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APA: Copy

SHIRAN, M.B., MOTEVALIAN, M., RAVANFAR, R., & BOHLOULI, SH.. (2008). THE EFFECT OF BUBBLE SURFACE CHARGE ON PHONOPHORESIS: IMPLICATION IN TRANSDERMAL PIROXICAM DELIVERY. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 7(1), 15-19. SID. https://sid.ir/paper/297178/en

Vancouver: Copy

SHIRAN M.B., MOTEVALIAN M., RAVANFAR R., BOHLOULI SH.. THE EFFECT OF BUBBLE SURFACE CHARGE ON PHONOPHORESIS: IMPLICATION IN TRANSDERMAL PIROXICAM DELIVERY. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2008;7(1):15-19. Available from: https://sid.ir/paper/297178/en

IEEE: Copy

M.B. SHIRAN, M. MOTEVALIAN, R. RAVANFAR, and SH. BOHLOULI, “THE EFFECT OF BUBBLE SURFACE CHARGE ON PHONOPHORESIS: IMPLICATION IN TRANSDERMAL PIROXICAM DELIVERY,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 7, no. 1, pp. 15–19, 2008, [Online]. Available: https://sid.ir/paper/297178/en

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