H2S: AN ENDOGENOUS GAS

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PATEL M.A.; SHAH G.B.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2008 | Volume:7 | Issue:1 Page(s): 1-10

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Information Journal Paper

Title

H2S: AN ENDOGENOUS GAS

Author(s)

PATEL M.A. | SHAH G.B. | Issue Writer Certificate

Keywords

HYDROGEN SULFIDE

ATP DEPENDANT K+ CHANNEL OPENER

VASORELAXATION

Abstract

gases, such as NO and CO, play important roles both in normal physiology and in diseases. In recent years, interest has been directed towards other naturally-occurring gases, notably H2S, which is produced n body by three enzymes, namely cystathionine beta synthase (CBS), cystathionine gamma lyase (CSE) nd 3-Mercaptopyruvate sulfurtransferase (MST), present in mitochondria and/or cytosols where main ubstrate is L-cysteine. Recent studies have shown that vascular tissues generate measurable amount of 2S. NO is considered as inducer for H2S. H2S has gained importance as a neuromodulator and a asorelaxant factor and as the first endogenous gaseous ATP dependant K+ channel opener. It potenti-tes LTP by enhancing NMDA induced inward current.H2S induces VASORELAXATION, inhibits insulin secre-ion and also has a role in inflammation. H2S also appear to have a role in neuroendocrine fuction be-ause it plays an important role in control of the hypothalamus-pitutary-adrenal axis, inhibit stimulated elease of corticotrophin-releasing hormone. H2S has been found to be decreased in patient with Alz-eimer’s disease and higher concentrations are found in patients with Down’s syndrome. It has a role in evelopment of hypertension, suggesting its role in CNS and CVS disorders. H2S it is well known toxic as with the smell of rotten eggs, is now proposed as a physiologically important molecule.

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APA: Copy

PATEL, M.A., & SHAH, G.B.. (2008). H₂S: AN ENDOGENOUS GAS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 7(1), 1-10. SID. https://sid.ir/paper/297182/en

Vancouver: Copy

PATEL M.A., SHAH G.B.. H₂S: AN ENDOGENOUS GAS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2008;7(1):1-10. Available from: https://sid.ir/paper/297182/en

IEEE: Copy

M.A. PATEL, and G.B. SHAH, “H₂S: AN ENDOGENOUS GAS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 7, no. 1, pp. 1–10, 2008, [Online]. Available: https://sid.ir/paper/297182/en

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