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Information Journal Paper

Title

ANALGESIC, ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF NEWLY-SYNTHESIZED BICYCLOTHIENO 1, 2, 3 - TRIAZINES

Pages

  31-38

Abstract

 The novel BICYCLO THIENO 1, 2, 3-TRIAZINES (BTT) namely BTT-1, BTT-2, BTT-3 and BTT-4 were evaluated for ANALGESIC, anti-inflammatory and ANTI-ARTHRITIC ACTIVITY. ANALGESIC and ANTI-INFLAMMATORY ACTIVITY was evaluated using hot plate test, formalin-induced paw licking test and formalin-induced paw edema test respectively. Complete fruend’s adjuvant (CFA) -induced arthritis model was used for ANTI-ARTHRITIC ACTIVITY. All test drugs showed significant ANALGESIC activity by increasing the reaction latency time in hot plate test and decreasing the number of lickings in formalin test. BTT-3 was found to be effective in both early and late phase, while all other test drugs were found to be effective only in late phase of nociception. In anti-inflammatory studies, the BTT-3 (25 and 50 mg/kg, i.p.) had significantly reduced the formalin-induced paw edema. In CFA-INDUCED ARTHRITIS models, the BTT-3 has showed activity from the 4th day of the treatment, while all the other test drugs have showed significant inhibition of CFA-induced paw edema from the 7th day of the treatment by decreasing the elevated levels of WBC, % Hb, ESR, along with decreasing the serum levels of C-reactive protein (CRP) and rheumatoid factor (RF). In conclusion, all test drugs were found to possess very good ANALGESIC, anti-inflammatory and ANTI-ARTHRITIC ACTIVITY and BTT-3 was found to be more potent compared to other compounds.

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    APA: Copy

    VISWANATHA, G.L., AKINAPALLY, NAGARAJU, KRISHNADAS, NANDAKUMAR, RANGAPPA, SRINATH, & JANARDHANAN, SARAVANAN. (2011). ANALGESIC, ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF NEWLY-SYNTHESIZED BICYCLOTHIENO 1, 2, 3 - TRIAZINES. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 10(1), 31-38. SID. https://sid.ir/paper/297225/en

    Vancouver: Copy

    VISWANATHA G.L., AKINAPALLY NAGARAJU, KRISHNADAS NANDAKUMAR, RANGAPPA SRINATH, JANARDHANAN SARAVANAN. ANALGESIC, ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF NEWLY-SYNTHESIZED BICYCLOTHIENO 1, 2, 3 - TRIAZINES. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2011;10(1):31-38. Available from: https://sid.ir/paper/297225/en

    IEEE: Copy

    G.L. VISWANATHA, NAGARAJU AKINAPALLY, NANDAKUMAR KRISHNADAS, SRINATH RANGAPPA, and SARAVANAN JANARDHANAN, “ANALGESIC, ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF NEWLY-SYNTHESIZED BICYCLOTHIENO 1, 2, 3 - TRIAZINES,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 10, no. 1, pp. 31–38, 2011, [Online]. Available: https://sid.ir/paper/297225/en

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