PREVALENCE AND RISK FACTORS FOR NON-VERTEBRAL FRACTURES IN PATIENTS RECEIVING ORAL GLUCOCORTICOIDS

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MANUEL SOSA HENRIQUEZ; ROMERO MARIA JESUS GOMEZ DE TEJADA; PEDRO SAAVEDRA SANTANA; JOSE ANTONIO BLAZQUEZ CABRERA; JESUS ALBERTO GARCIA VADILLO; CARMEN VALDES LIORCA; MANUEL DIAZ CURIEL; MANUEL MUNOZ TORRES; MARIA ELENA MARTINEZ RODRIGUEZ; CARMEN NAVARRO CEBALLOS; JOSE SANFELIX GENOVES; MARIA JESUS CANCELO HIDALGO; PEDRO CARPINTERO BENITEZ; MANUEL MESA RAMOS; ANTUNANO SANTIAGO PALACIOS GIL

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Journal: International Journal of Endocrinology and Metabolism Year:2012 | Volume:10 | Issue:2 Page(s): 480-485

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Title

PREVALENCE AND RISK FACTORS FOR NON-VERTEBRAL FRACTURES IN PATIENTS RECEIVING ORAL GLUCOCORTICOIDS

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Keywords

ADRENAL CORTEX HORMONES

OSTEOPOROSIS

Abstract

Introduction: Glucocorticoids taken orally increase the risk of fractures. It has been noted that a dose as low as 2.5 mg/day increases the risk of vertebral fracture. What is less clear is the possible influence of other risk factors for OSTEOPOROSIS on the presence of non-vertebral fractures in patients taking glucocorticoids.Patients and Methods: A cross-sectional study, performed on 513 men and women from Spain, who were taking at least 7.5 mg/day of oral prednisone for a minimum of 3 months. A questionnaire was developed, through which information on risk factors was collected.Results: 28.3% of the patients who were taking glucocorticoids at a daily oral dose of 7.5 mg/ day for a minimum of 3 months had suffered at least one non-vertebral fracture. The risk increased with age, the number of months the glucocorticoids had been taken, the presence of falls in the last year and, above all, with a maternal history of hip fracture.Conclusions: In patients taking oral glucocorticoids for over 3 months at doses higher than 7.5 mg/day of prednisone or equivalent, the prevalence of non-vertebral fractures was 28.3%. Some risk factors associated with the presence of these fractures were identified. The duration of glucocorticoid use appears to be more strongly related to the presence of non-vertebral fractures than the daily dose.

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APA: Copy

MANUEL, SOSA HENRIQUEZ, ROMERO MARIA JESUS, GOMEZ DE TEJADA, PEDRO, SAAVEDRA SANTANA, JOSE ANTONIO, BLAZQUEZ CABRERA, JESUS ALBERTO, GARCIA VADILLO, CARMEN, VALDES LIORCA, MANUEL, DIAZ CURIEL, MANUEL, MUNOZ TORRES, MARIA ELENA, MARTINEZ RODRIGUEZ, CARMEN, NAVARRO CEBALLOS, JOSE, SANFELIX GENOVES, MARIA JESUS, CANCELO HIDALGO, PEDRO, CARPINTERO BENITEZ, MANUEL, MESA RAMOS, & ANTUNANO SANTIAGO, PALACIOS GIL. (2012). PREVALENCE AND RISK FACTORS FOR NON-VERTEBRAL FRACTURES IN PATIENTS RECEIVING ORAL GLUCOCORTICOIDS. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(2), 480-485. SID. https://sid.ir/paper/297436/en

Vancouver: Copy

MANUEL SOSA HENRIQUEZ, ROMERO MARIA JESUS GOMEZ DE TEJADA, PEDRO SAAVEDRA SANTANA, JOSE ANTONIO BLAZQUEZ CABRERA, JESUS ALBERTO GARCIA VADILLO, CARMEN VALDES LIORCA, MANUEL DIAZ CURIEL, MANUEL MUNOZ TORRES, MARIA ELENA MARTINEZ RODRIGUEZ, CARMEN NAVARRO CEBALLOS, JOSE SANFELIX GENOVES, MARIA JESUS CANCELO HIDALGO, PEDRO CARPINTERO BENITEZ, MANUEL MESA RAMOS, ANTUNANO SANTIAGO PALACIOS GIL. PREVALENCE AND RISK FACTORS FOR NON-VERTEBRAL FRACTURES IN PATIENTS RECEIVING ORAL GLUCOCORTICOIDS. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2012;10(2):480-485. Available from: https://sid.ir/paper/297436/en

IEEE: Copy

SOSA HENRIQUEZ MANUEL, GOMEZ DE TEJADA ROMERO MARIA JESUS, SAAVEDRA SANTANA PEDRO, BLAZQUEZ CABRERA JOSE ANTONIO, GARCIA VADILLO JESUS ALBERTO, VALDES LIORCA CARMEN, DIAZ CURIEL MANUEL, MUNOZ TORRES MANUEL, MARTINEZ RODRIGUEZ MARIA ELENA, NAVARRO CEBALLOS CARMEN, SANFELIX GENOVES JOSE, CANCELO HIDALGO MARIA JESUS, CARPINTERO BENITEZ PEDRO, MESA RAMOS MANUEL, and PALACIOS GIL ANTUNANO SANTIAGO, “PREVALENCE AND RISK FACTORS FOR NON-VERTEBRAL FRACTURES IN PATIENTS RECEIVING ORAL GLUCOCORTICOIDS,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 2, pp. 480–485, 2012, [Online]. Available: https://sid.ir/paper/297436/en

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